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Abnormal optic disc and retinal vessels in children with surgically treated hydrocephalus
  1. S Andersson1,
  2. A Hellström1,2
  1. 1
    Department of Ophthalmology, Institute of Clinical Neuroscience and Physiology, Göteborg, Sweden
  2. 2
    International Paediatric Growth Research Centre, Department of Paediatrics, Institute of the Health of Women and Children, The Sahlgrenska Academy of Göteborg University, Göteborg, Sweden
  1. Dr S Andersson, Department of Ophthalmology, The Queen Silvia Children’s Hospital, Sahlgrenska University Hospital/Östra, 416 85 Göteborg, Sweden; susann.andersson{at}oft.gu.se

Abstract

Aims: To investigate the morphology of the optic disc and retinal vessels in children with surgically treated hydrocephalus.

Methods: A prospective, population-based study was performed in 69 children (median age 9.6 years) with early surgically treated hydrocephalus. All children were examined by ophthalmoscopy. Additionally, optic disc and retinal vessel morphology was evaluated in 55 children by digital image analysis of ocular fundus photographs.

Results: Optic atrophy was found in 10 of 69 children (14%). In comparison with a reference group, the median optic-disc area was significantly smaller (p = 0.013) in the children with hydrocephalus. There was no corresponding difference in cup area, so the rim area was significantly smaller in the hydrocephalic children (p = 0.002). Children with hydrocephalus had an abnormal retinal vascular pattern, with significantly straighter retinal arteries and fewer central vessel branching points compared with controls (p<0.001 and p<0.001, respectively).

Conclusion: Hydrocephalus is associated with subnormal optic disc and rim areas and an abnormal vascular pattern, indicating a pre/perinatal disturbance of the development of these structures. A promising finding is that the frequency of optic atrophy in the present study was lower than previously reported, most likely reflecting improved perinatal care and better regulation of the intracranial pressure.

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Footnotes

  • Funding: This work was supported by grants from the Göteborg Medical Society, the Föreningen De Blindas Vänner, the Petter Silfverskiöld Memory Foundation, and W & M Lundgren’s Science Foundation.

  • Competing interests: None.

  • Ethics approval: Ethics approval was provided by the Medical Faculty, Göteborg University.

  • Patient consent: Obtained from the parents.

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