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Short-term effect of intravitreal anti-VEGFs delivery on intraocular pressure
  1. S Nabili1,
  2. M Stevenson2,
  3. U Chakravarty1,3,
  4. T Moutray1
  1. 1
    Directorate of Ophthalmology, Head and Skeletal Division, Royal Victoria Hospital Belfast, Belfast, UK
  2. 2
    Centre for Population Sciences, The Queen’s University of Belfast, Belfast, UK
  3. 3
    Centre for Vision Sciences, The Queen’s University of Belfast, Belfast, UK
  1. Dr T Moutray, Department of Ophthalmology, Royal Victoria Hospital, Belfast, UK; tanya.moutray{at}btopenworld.com

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Since the successful introduction of antivascular endothelial growth factor (VEGF) intravitreal injections (IVT) for the management of age-related macular degeneration (AMD), this treatment has gained popularity. Several studies have reported on the complications of anti-VEGF IVT, including a transient rise in intraocular pressure (IOP).1

We aimed to determine whether IOP measurement post-IVT is necessary following injection of the commonly used anti-VEGF agents: ranibizumab (Lucentis), bevacizumab (Avastin) and pegabtanib (Macugen).

METHOD

This was a retrospective observational study of postinjection change in IOP in patients with neovascular AMD who received an injection of an anti-VEGF drug between September 2006 and March 2008. Patients were treated with one of three anti-VEGF drugs (ranibizumab 0.5 mg, bevacizumab 1.25 mg, pegabtanib 0.3 mg) using a sterile technique. Povidine iodine 5% preparation and topical oxybuprocaine anaesthetic …

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