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  • Evaluation of keratic precipitates and corneal endothelium in Fuchs’ heterochromic cyclitis by in vivo confocal microscopy

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Original Article
Evaluation of keratic precipitates and corneal endothelium in Fuchs’ heterochromic cyclitis by in vivo confocal microscopy
  1. A Labbé1,2,
  2. B Dupas1,
  3. H Offret3,
  4. C Baudouin1,2,
  5. M Labetoulle3
  1. 1
    Department of Ophthalmology, Quinze-Vingts National Ophthalmology Hospital, Paris, France
  2. 2
    INSERM UMR S872, Les Cordeliers, Université Pierre et Marie Curie-Paris 6, Université Paris Descartes-Paris 5, Paris, France
  3. 3
    Department of Ophthalmology, Hôpital de Bicêtre, Assistance Publique-Hôpitaux de Paris, Université Paris Sud, Paris, France
  1. Dr A Labbé, Service d’Ophtalmologie III, CHNO des Quinze-Vingts, 28 rue de Charenton, 75012 Paris, France; antoinelabbe{at}hotmail.com

Abstract

Purpose: To analyse keratic precipitates in Fuchs’ heterochromic cyclitis (FHC) by in-vivo confocal microscopy (IVCM).

Patients and methods: A retrospective chart review of 13 consecutive patients with FHC was conducted. Data collection included medical and ophthalmological history, age, age at diagnosis, gender, detailed slit-lamp examination and IVCM images. The IVCM characteristics of keratic precipitates and of the endothelium were analysed.

Results: Large hyperreflective deposits corresponding to keratic precipitates were observed on the endothelium of all FHC eyes and showed a great consistency among the different patients. These infiltrating keratic precipitates had a dendritic shape, with a small central core with numerous thin pseudopodia sometimes making connection between different keratic precipitates. The mean density of these keratic precipitates was 16.01/mm2 (SD 6.54). The mean size of the largest dimension of these keratic precipitates was 127.31 μm (SD 41.49; range 66.16–201.4 μm). Hyporeflective round defects were observed at the level of the endothelium at contact or in the close vicinity of keratic precipitates or smaller hyperreflective deposits. All contralateral (non-affected eyes) had no keratic precipitates nor endothelial abnormalities.

Conclusions: By providing high resolution images of corneal endothelium and keratic precipitates, IVCM could help the diagnosis and understanding of complex forms of intraocular inflammation such as FHC.

https://doi.org/10.1136/bjo.2008.146100

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    Footnotes

    • Competing interests: None.

    • Funding: Supported by Quinze-Vingts National Ophthalmology Hospital, Paris, France.

    • This paper was presented in part as a poster at the annual meeting of the Association for Research in Vision and Ophthalmology, Fort Lauderdale, Florida, USA, May 2007.

    • Ethics approval: Ethics approval was obtained.