rss
Br J Ophthalmol 2009;93:673-677 doi:10.1136/bjo.2008.146100
  • Clinical science
    • Original Article

Evaluation of keratic precipitates and corneal endothelium in Fuchs’ heterochromic cyclitis by in vivo confocal microscopy

  1. A Labbé1,2,
  2. B Dupas1,
  3. H Offret3,
  4. C Baudouin1,2,
  5. M Labetoulle3
  1. 1
    Department of Ophthalmology, Quinze-Vingts National Ophthalmology Hospital, Paris, France
  2. 2
    INSERM UMR S872, Les Cordeliers, Université Pierre et Marie Curie-Paris 6, Université Paris Descartes-Paris 5, Paris, France
  3. 3
    Department of Ophthalmology, Hôpital de Bicêtre, Assistance Publique-Hôpitaux de Paris, Université Paris Sud, Paris, France
  1. Dr A Labbé, Service d’Ophtalmologie III, CHNO des Quinze-Vingts, 28 rue de Charenton, 75012 Paris, France; antoinelabbe{at}hotmail.com
  • Accepted 12 November 2008
  • Published Online First 17 December 2008

Abstract

Purpose: To analyse keratic precipitates in Fuchs’ heterochromic cyclitis (FHC) by in-vivo confocal microscopy (IVCM).

Patients and methods: A retrospective chart review of 13 consecutive patients with FHC was conducted. Data collection included medical and ophthalmological history, age, age at diagnosis, gender, detailed slit-lamp examination and IVCM images. The IVCM characteristics of keratic precipitates and of the endothelium were analysed.

Results: Large hyperreflective deposits corresponding to keratic precipitates were observed on the endothelium of all FHC eyes and showed a great consistency among the different patients. These infiltrating keratic precipitates had a dendritic shape, with a small central core with numerous thin pseudopodia sometimes making connection between different keratic precipitates. The mean density of these keratic precipitates was 16.01/mm2 (SD 6.54). The mean size of the largest dimension of these keratic precipitates was 127.31 μm (SD 41.49; range 66.16–201.4 μm). Hyporeflective round defects were observed at the level of the endothelium at contact or in the close vicinity of keratic precipitates or smaller hyperreflective deposits. All contralateral (non-affected eyes) had no keratic precipitates nor endothelial abnormalities.

Conclusions: By providing high resolution images of corneal endothelium and keratic precipitates, IVCM could help the diagnosis and understanding of complex forms of intraocular inflammation such as FHC.

Footnotes

  • Competing interests: None.

  • Funding: Supported by Quinze-Vingts National Ophthalmology Hospital, Paris, France.

  • This paper was presented in part as a poster at the annual meeting of the Association for Research in Vision and Ophthalmology, Fort Lauderdale, Florida, USA, May 2007.

  • Ethics approval: Ethics approval was obtained.

This Article

  1. Abstract
  2. Full text
  3. PDF
  4. All Versions of this Article:
    1. bjo.2008.146100v1
    2. 93/5/673 most recent

Services

  1. Email this link to a friend
  2. Alert me when this article is cited
  3. Alert me if a correction is posted
  4. Alert me when eletters are published
  5. Article Usage Statistics
  6. Similar articles in this journal
  7. Similar articles in Web of Science
  8. Similar articles in PubMed
  9. Add article to my folders
  10. Download to citation manager
  11. Request permissions

Responses

  1. Submit a response
  2. No responses published

Social bookmarking

Register for free content


Free sample
 This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of BJO.
View free sample issue >>

Free archive
The full back archive is now available for BJO. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006, back to volume 1 issue 1.
Register to access the free archive >>

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.