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Br J Ophthalmol 2009;93:782-786 doi:10.1136/bjo.2008.144535
  • Clinical science
    • Original Article

A randomised crossover study comparing bimatoprost and latanoprost in subjects with primary angle closure glaucoma

  1. A C S How1,
  2. R S Kumar2,
  3. Y-M Chen3,
  4. D H Su1,
  5. H Gao3,
  6. F T Oen1,
  7. C-L Ho1,
  8. S K Seah1,
  9. T Aung1,2,4
  1. 1
    Singapore National Eye Centre, Singapore
  2. 2
    Singapore Eye Research Institute, Singapore
  3. 3
    Clinical Trials and Epidemiology Research Unit, Singapore
  4. 4
    Yong Loo Lin School of Medicine, National University of Singapore, Singapore
  1. Dr T Aung, Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore 168751; tin11{at}pacific.net.sg
  • Accepted 20 December 2008
  • Published Online First 30 March 2009

Abstract

Background/aims: To compare the intraocular pressure (IOP) lowering efficacy and side effects of latanoprost 0.005% and bimatoprost 0.03% in subjects with chronic primary angle closure glaucoma (PACG).

Methods: This was an observer-masked randomised crossover study of 60 PACG subjects who received either latanoprost or bimatoprost for 6 weeks, after which they were crossed over to the other medication for another 6 weeks. The IOP-reducing effect of the medications was assessed by the reduction in IOP after 6 weeks of treatment compared with baseline.

Results: Fifty-four subjects (80 eyes) completed the study. Latanoprost reduced IOP (mean (SD)) by 8.4 (3.8) mm Hg and bimatoprost by 8.9 (3.9) mm Hg from a baseline of 25.2 (3.6) mm Hg and 25.2 (3.6) mm Hg respectively (p = 0.23). Adverse events were mild in both groups; however there were twice as many reports of an adverse event in the bimatoprost group (81%) compared with the latanoprost group (40%, p<0.01). Ocular irritation was the most frequently reported adverse event in both groups; 22 subjects (37.9%) treated with bimatoprost experienced ocular hyperaemia as compared with 13 subjects (22.4%) treated with latanoprost (p = 0.11).

Conclusions: Bimatoprost once daily was similarly effective in reducing IOP compared with latanoprost once daily in subjects with chronic PACG. Both drugs were well tolerated with mild ocular adverse events.

Footnotes

  • Competing interests: TA has received research funding, travel support and honoraria from Allergan and has been a consultant and received travel support and honoraria from Pfizer.

  • Funding: This research was funded by an unrestricted grant from Allergan.

  • Ethics approval: Ethics approval was provided by the Ethics Committee of the Singapore Eye Research Institute.

  • Patient consent: Obtained.

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