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Intraocular sarcoidosis: association of clinical characteristics of uveitis with positive chest high-resolution computed tomography findings
  1. Dominique S Clement1,
  2. Gina Postma2,
  3. Aniki Rothova2,
  4. Jan C Grutters3,4,
  5. Mathias Prokop1,
  6. Pim A de Jong1
  1. 1Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
  2. 2Department of Opthalmology, University Medical Center Utrecht, Utrecht, The Netherlands
  3. 3Department of Pulmonology, University Medical Center Utrecht, Utrecht, The Netherlands
  4. 4Department of Pulmonology, St Antonius Hospital, Nieuwegein, The Netherlands
  1. Correspondence to Dr Pim A de Jong, University Medical Centre Utrecht, Department of Radiology, HP E.01.132, Heidelberglaan 100, Utrecht 3584 CX, The Netherlands; pimdejong{at}gmail.com

Abstract

Aim To assess specific clinical criteria in patients with uveitis that are related to signs of sarcoidosis on high-resolution computed tomography (HRCT) of the chest.

Methods Retrospective study of 50 consecutive patients with uveitis who were referred for chest HRCT because of suspicion of sarcoidosis. Clinical characteristics, laboratory findings, chest radiographs and chest HRCT scans were retrieved. HRCT scans were reassessed for signs of sarcoidosis. Mann–Whitney and Fisher exact test were used for data analysis.

Results Ten of 50 (20%) uveitis patients referred for HRCT demonstrated signs of sarcoidosis on HRCT. The median age of these patients was significantly higher than those patients with a negative HRCT (71.1 vs 44.7 years, p=0.002). The presence of peripheral chorioretinal punched out lesions and posterior synechiae were significantly related to an abnormal HRCT scan.

Conclusion Increasing age, presence of peripheral multifocal chorioretinitis and posterior synechiae were associated with an abnormal HRCT scan.

  • Uveitis
  • sarcoidosis
  • CT
  • multifocal chorioretinitis
  • posterior chamber
  • inflammation
  • imaging
  • diagnostic tests/investigation

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Footnotes

  • Competing interests None.

  • Ethics approval Ethics approval was provided by the ethical review board of the University Medical Center Utrecht approved the study.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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