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Neurodevelopmental outcomes with congenital ocular motor apraxia
  1. A Paula Grigorian1,
  2. Katherine J Fray1,
  3. Michael C Brodsky2,
  4. Paul H Phillips1
  1. 1University of Arkansas Medical Center and Arkansas Children's Hospital, Little Rock, Arkansas, USA
  2. 2Mayo Clinic, Rochester, Minnesota, USA
  1. Correspondence to Dr Paul H Phillips, Arkansas Children's Hospital, 1 Children's Way, Little Rock, AR 72202, USA; phillipspaulh{at}

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The unique ocular motility dysfunction in isolated congenital ocular motor apraxia (COMA) is well characterised.1 Clinical findings include difficulty initiating horizontal saccades, horizontal head thrusting and relative preservation of vertical eye movements. In the European literature, COMA is referred to as Horizontal Saccadic Initiation Failure.2

Previous investigators have described the ocular motility dysfunction in patients with COMA.2 However, the neurodevelopmental profile of these patients has not been systematically investigated.3 The purpose of this study is to characterise the neurodevelopmental outcome in patients with COMA.


We retrospectively analysed the medical records of all children diagnosed with COMA at Arkansas Children's Hospital between 1993 and 2007. These patients were identified from a database that includes the diagnosis of all patients evaluated in the ophthalmology clinic during this time interval. Each patient had a complete ophthalmological examination as well as a developmental history, including questions regarding motor coordination, gait, language development, intellectual ability and school performance. The developmental status was determined from a review of the medical records from the ophthalmology clinic and …

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