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Comparison of infliximab versus ciclosporin during the initial 6-month treatment period in Behçet disease
  1. Yukiko Yamada,
  2. Sunao Sugita,
  3. Hiroyuki Tanaka,
  4. Koju Kamoi,
  5. Tatsushi Kawaguchi,
  6. Manabu Mochizuki
  1. Department of Ophthalmology & Visual Science, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo, Japan
  1. Correspondence to Professor Manabu Mochizuki, Department of Ophthalmology & Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan; m.manabu.oph{at}tmd.ac.jp

Abstract

Aim To compare the efficacy and safety of infliximab versus ciclosporin A (CsA) in refractory uveoretinitis in Behçet disease.

Methods In this retrospective clinical chart review of patients with Behçet disease who were treated with CsA or infliximab, we collected information on the number of uveitis attacks, visual acuity and adverse side effects that occurred during the 6 months prior to and after the initiation of CsA (n=20) or infliximab (n=17).

Results The number of acute episodes of uveitis during the 6 months before and after initiation of CsA were 3.3±2.4 and 1.2±1.2, and those of infliximab were 3.1±2.7 and 0.4±1.0, respectively (p<0.005). The number of episodes after infliximab administration was significantly lower than that seen for CsA (p<0.05). During the 6-month treatment period, there were no significant differences noted in the improvement of the visual acuity between the two therapies. After CsA administration, neurological symptoms and renal toxicity were seen in one patient each, while after the infliximab administration, an infusion reaction and leucopenia were seen in one patient each.

Conclusion During the initial 6 months of treatment, infliximab proved to be more effective in reducing acute episodes of uveitis in Behçet disease.

  • Behçet disease
  • anti-TNF-α
  • antibody
  • uveoretinitis
  • ciclosporin A
  • immunology
  • inflammation
  • treatment medical

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Footnotes

  • Competing interests None.

  • Ethics approval Ethics approval was provided by the Institutional Ethics Committee of Tokyo Medical and Dental University Hospital.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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