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A 30-month prospective study on the treatment of retinoblastoma in the Gabriel Touré Teaching Hospital, Bamako, Mali
  1. Togo Boubacar1,
  2. Sylla Fatou2,
  3. Traoré Fousseyni1,
  4. Sylla Mariam1,
  5. Dicko-Traoré Fatoumata1,
  6. Sidibé Toumani1,
  7. Diakité Abdoul-Aziz1,
  8. Keïta Mamadou Marouf1
  1. 1Paediatric Service of Gabriel Touré Hospital, Bamako, Mali
  2. 2Tropical Ophthalmology Institute (IOTA), Bamako, Mali
  1. Correspondence to Dr Togo Boubacar, Paediatric Service of Gabriel Touré Hospital, Bamako BP 267, Mali; togoboubacar2000{at}yahoo.fr

Abstract

Introduction Retinoblastoma is one of the most common malignant tumours among children in Africa. However, very few studies on this disease have been published, especially studies from French-speaking countries in Africa.

Patients and methods Prospective study over a period of 30 months from 1 January 2005 to 30 June 2007 on all cases of retinoblastoma diagnosed and treated in the Paediatric Oncology Unit of the Gabriel Touré Hospital in Bamako, Mali. Treatment was two courses of pre-operative chemotherapy (cyclophosphamide, adriamycine and vincristine), enucleation for many patients, and then two courses of adjuvant chemotherapy with the same drugs.

Results During the study period, 55 cases of retinoblastoma were treated, which represents 33.1% of all the solid tumours, coming second in frequency after lymphomas (39.7%). The mean age of the patients was 4.2 years. Boys were the most affected, with a sex ratio of 2:1. Forty-nine mothers (89.1%) and 46 fathers (83.6%) had no formal education. Thirty-seven children (67.3%) were from rural areas. Unilateral cases were predominant (49 cases (89.1%)). Ten cases (10.9%) were bilateral. Exophthalmos was the leading symptom (30 cases (54.5%)). The survival rate at 30 months was 56% with 18% lost at follow-up.

Conclusion Mortality as a result of retinoblastoma remains high in our region because diagnosis is always late and it is difficult to follow-up the patients. Education of healthcare workers and raising awareness in the general population would improve the survival rate of retinoblastoma patients in Africa.

  • Africa
  • late diagnosis
  • posterior chamber
  • retina
  • retinoblastoma
  • survival
  • optic nerves
  • orbit
  • visual pathway

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Footnotes

  • Funding Groupe Franco Africain d'Oncologie Pédiatrique, Institut Gustave Roussy, Villejuif, France.

  • Competing interests None declared.

  • Ethics approval This study was conducted with the approval of the Ethics Committee Mali.

  • Patient consent Obtained from the parents of the children in the study.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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