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Lack of evidence for a link between latanoprost use and malignant melanoma: an analysis of safety databases and a review of the literature
  1. Charles S Tressler1,
  2. Robert L Wiseman1,
  3. Theresa M Dombi2,
  4. Bart Jessen3,
  5. Kui Huang1,
  6. Kenneth K Kwok1,
  7. Barbara M Wirostko4
  1. 1Pfizer Inc., New York, New York, USA
  2. 2Pfizer Inc., Groton, Connecticut, USA
  3. 3Pfizer Inc., San Diego, California, USA
  4. 4Department of Ophthalmology, University of Utah, Moran Eye Center, Salt Lake City, Utah, USA
  1. Correspondence to Charles S Tressler, Pfizer Inc., 235 East 42nd Street, New York, NY 10017, USA; charles.s.tressler{at}pfizer.com

Abstract

Aim To determine if there is an association between the use of latanoprost ophthalmic solution and malignant melanoma and to assess the evidence of a plausible biological mechanism.

Methods Two safety databases were reviewed: one representing all latanoprost (n=24) and fixed-combination latanoprost/timolol (n=16) clinical trials conducted from November 1992 through November 2007 and a global safety database of all spontaneous non-trial-related clinical reports spanning 13 and 9 years for latanoprost and for latanoprost/timolol, respectively. A systematic PubMed search for studies evaluating potential mechanisms was conducted.

Results Amongst 12 880 latanoprost-treated subjects in clinical trials, no reported cases of ocular melanoma and three cases of cutaneous melanoma were identified. Of 19 940 cases recorded in the global safety database, 22 reports of ocular/cutaneous neoplasms were identified. Of these neoplasms, 11 were ocular and six were cutaneous melanomas. Possible association with latanoprost use could not be excluded in three ocular and one periorbital report. In vitro and in vivo data were consistent with a mechanism whereby the increased iris pigmentation results from stimulation of melanin synthesis by induction of tyrosinase transcription without increasing mitotic activity.

Conclusion There is no evidence at present that establishes a link between latanoprost use and either ocular or cutaneous melanoma.

  • Melanoma
  • latanoprost
  • skin neoplasms
  • eye neoplasms
  • neoplasia
  • treatment medical

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Footnotes

  • Funding This study was supported by Pfizer Inc., New York. Linda Whetter of Zola Associates provided editorial support, including updating the literature search, contributing to the first draft of the paper, revising the paper based on author comments and styling the paper for journal submission.

  • Competing interests CST, RLW, TMD, BJ, KH and KKK are all employees of Pfizer Inc. BMW was an employee of Pfizer Inc. at the time of the study conduct and manuscript development.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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