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Incorrect study design and analysis: the effect of genetic variants in SERPING1 on the risk of neovascular age-related macular degeneration
  1. Gerald McGwin Jr1,2
  1. 1Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
  2. 2Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama, USA
  1. Correspondence to Gerald McGwin, Departments of Epidemiology and Ophthalmology, University of Alabama at Birmingham, 609 Eye Foundation Hospital, 1720 University Boulevard, Birmingham, AL 35294, USA; mcgwin{at}uab.edu

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The recently published study by Lee et al1 is described as a retrospective cohort study; however, this is incorrect. The study subjects were selected on the basis of having neovascular age-related macular degeneration (AMD) or not, and the two groups being matched with respect to ethnicity. The frequency of individual genotypes was then compared between …

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