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Latanoprost and malignant melanoma
Tressler et al determined if there is any association between the use of latanoprost ophthalmic solution and malignant melanoma by reviewing two safety databases: one representing all latanoprost (n1/424) and fixed-combination latanoprost/timolol (n1/416) clinical trials and a global safety database of all non-trial-related clinical reports (1992–2007). Among 12 880 latanoprost-treated subjects in clinical trials, no case of ocular melanoma and three cases of cutaneous melanoma were identified. Of 19 940 cases recorded in the global safety database, 22 reports of ocular/cutaneous neoplasms were identified. In vitro and in vivo data indicate that latanoprost stimulates melanin synthesis by induction of tyrosinase transcription without increasing mitotic activity. The authors conclude that there is no evidence to link latanoprost use and risk of ocular or cutaneous melanoma (see page 1490).
Collagen cross-linkage for keratoconus
O'Brart et al performed a randomised study to investigate the …
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