Article Text

PDF
Original article
Angiography features of early onset drusen
  1. Benjamin Guigui,
  2. Nicolas Leveziel,
  3. Virginie Martinet,
  4. Nathalie Massamba,
  5. Margaret Sterkers,
  6. Gabriel Coscas,
  7. Eric H Souied
  1. Creteil University Eye Clinic, Faculte de Medecine Henri Mondor, Creteil, France
  1. Correspondence to Dr Eric Souied, Creteil University Eye Clinic, 40 avenue de Verdun, 94010 Créteil, France; esouied{at}hotmail.com

Abstract

Aims Drusen are rarely observed in patients <50 years of age. Two types of early onset drusen (EOD) are commonly described: basal laminar drusen (BLD) and drusen associated with Malattia Leventinese (ML). Our purpose was to classify the phenotype of EOD on the basis of fundus examination, and fluorescein angiography (FA) and indocyanine green angiography (ICGA) features.

Methods We performed a prospective study including 48 consecutive EOD patients. All of them had a complete ophthalmologic examination including FA and ICGA.

Results BLD (67%) were extremely hyperfluorescent on FA and ICGA. ML (10%) was characterised by a combination of small radial and large round drusen with differences in staining in both FA and ICGA. We evidenced a third type of EOD (23%) harbouring an aspect of large colloid drusen (LCD), mildly hyperfluorescent in the early phases of FA, with a progressive staining in late phases. In intermediate and late phases of ICGA, LCD presented as hypofluorescent dot surrounded by a hyperfluorescent halo bordered by a thin hypofluorescent ring.

Conclusion Three types of EOD are distinguished by their FA and ICGA features. We report a new kind of juvenile drusen, distinct from BLD and ML, named LCD, associated with a good vision and absence of complications.

  • Basal laminar drusen
  • Malattia Leventinese
  • fluorescein angiography
  • indocyanine green angiography
  • large colloid drusen
  • retina
  • macula
  • imaging

Statistics from Altmetric.com

Footnotes

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval This study was performed in agreement with the Declaration of Helsinki for research involving human subjects, and in agreement with our local ethics committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.