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Varicella zoster virus (VZV) causes latent human infection, and its reactivations have been associated with insufficient cellular immunity. Occasional studies have linked a reactivation of VZV infection to vaccination against other (non-herpes) viruses, specifically flu vaccination.1–3 VZV-related acute retinal necrosis (ARN) is a devastating disease with poor visual prognosis, during which necrotic areas develop in the peripheral retina and rapidly progress. The recent hypothesis on ARN pathogenesis assumes the presence of the latent virus in the neural tissue and attributes the development of ARN to the reactivation of the virus due to a (temporary) decrease in cellular immunity.
We report on a recurrence of bilateral VZV-associated panuveitis following vaccination against flu H1N1 in a 60-year-old male patient with previous VZV-induced ARN after …