Article Text

PDF
Original article
Expression of HSP 90, PTEN and Bcl-2 in conjunctival melanoma
  1. Henrike Westekemper1,
  2. Sara Karimi1,
  3. Daniela Süsskind2,
  4. Gerasimos Anastassiou1,
  5. Michael Freistühler1,
  6. Klaus-Peter Steuhl1,
  7. Norbert Bornfeld1,
  8. Kurt-Werner Schmid3,
  9. Florian Grabellus3
  1. 1Department of Ophthalmology, University of Duisburg-Essen, Essen, Germany
  2. 2Department of Ophthalmology, Eberhard-Karls University Tübingen, Tübingen, Germany
  3. 3Institute of Pathology and Neuropathology, University of Duisburg-Essen, Essen, Germany
  1. Correspondence to Dr Florian Grabellus, Institute of Pathology and Neuropathology, University of Duisburg-Essen, Hufelandstr. 55, D-45122 Essen, Germany; florian.grabellus{at}uk-essen.de

Statistics from Altmetric.com

Background

In the differential diagnosis of conjunctival melanocytic lesions, HMB45, S100 and Melan-A (MART-1) became the most important immunohistological antigens that help to distinguish melanomas from benign melanocytic lesions of the conjunctiva.1 S100, an acidic protein, and Melan-A, a melanosomal antigen, both mark the extension of a melanocytic lesion.2 3 Jakobiec et al showed that S100 A1 improves the diagnostic assessment of conjunctival nevi and melanomas.2 HMB45, a cytoplasmic oncofetoprotein, is a marker for a low grade of differentiation.4 Its expression is increased in conjunctival melanoma and primary acquired melanosis (PAM) with atypia.1 HMB 45, Melan-A, S100 and Ki67 as a proliferation index became part of the …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles

  • At a glance
    Harminder S Dua Arun D Singh