Glaucoma prevalence in Indigenous Australians
- Brian E Chua1,
- Jing Xie1,2,
- Anna-Lena Arnold1,2,
- Ignatios Koukouras1,
- Jill E Keeffe1,2,
- Hugh R Taylor2,3
- 1Centre for Eye Research Australia, Department of Ophthalmology, University of Melbourne, Australia and Royal Victorian Eye & Ear Hospital, Melbourne, Australia
- 2Vision CRC, Sydney, Australia
- 3Melbourne School of Population Health, University of Melbourne, Melbourne, Australia
- Correspondence to Professor Hugh Taylor, Melbourne School of Population Health, University of Melbourne, 207 Bouverie Street, Carlton, Victoria 3053, Australia;
- Accepted 28 October 2010
- Published Online First 27 November 2010
Aim Define the prevalence of glaucoma within the Indigenous Australian population.
Methods Aboriginal and Torres Strait Islander adults aged ≥40 years were recruited from 30 randomly selected sample areas or communities. Participants were regarded to have glaucoma if they had a cup:disc ratio (CDR) of >0.8, or missed ≥2 points on the Frequency Doubling Test and a CDR >0.7 in at least one eye.
Results 1189 eligible adult participants were examined, representing 72% of the target population. After excluding cases with missing or ungradable information, the authors found a 2.2% (95% CI 1.6% to 3.6%) overall prevalence of glaucoma. In univariate analyses, the odds of glaucoma increased with age (χ2 trend=4.38, p<0.001), male gender (OR 2.43, 95% CI 1.10 to 5.41), less than secondary education (OR 4.74, 95% CI 1.96 to 11.45) and self-reported history of glaucoma (OR 20.8; 95% CI 6.23 to 69.51). After a multivariate analysis, none of these attributes other than history of glaucoma remained significant. No cases of low vision (presenting visual acuity (VA) <6/12 to ≤6/60) or blindness (presenting VA<6/60) were solely attributable to glaucoma. The mean optic disc diameter was 1.93 mm (SD 0.19) for left and right eyes, while the mean CDR for right eyes was 0.44 (SD 0.15) and for left eyes 0.43 (SD 0.16).
Conclusions This population-based study examined the prevalence of glaucoma within the Indigenous Australian population, and although an infrequent cause of vision loss, definable rates of disease were seen. The results may suggest a potential introduction of Caucasian glaucoma-associated genes into this community, differently used diagnostic criteria or sampling bias compared with previous surveys.
Competing interests None.
Ethics approval Ethics approval was provided by the Royal Victorian Eye & Ear Hospital, Aboriginal Health and Medical Research Council of NSW, Aboriginal Health Council of South Australia, Menzies School of Health Research, Central Australia Human Research Ethics Committee, Western Australia Aboriginal Health Information and Ethics Committee, ACT Health, Tasmania Scientific Research Advisory Committee, Tasmania Health and Medical Human Research Ethics Committee, Queensland Aboriginal and Islander Health Council.
Provenance and peer review Not commissioned; externally peer reviewed.