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Br J Ophthalmol 96:62-67 doi:10.1136/bjo.2010.193581
  • Clinical science

Impairment of contrast visual acuity as a functional correlate of retinal nerve fibre layer thinning and total macular volume reduction in multiple sclerosis

Table 3

Results of linear regression analyses (LR) and Generalised Estimating Equations (GEEs) (from multiple sclerosis patients only) with retinal nerve fibre layer thickness (RNFLT) (first column) or total macular volume (TMV) (second column) and visual acuity (VA) and age as independent variables, and area under the curve (AUC) day (first row) or AUC Night (second row) as dependent variables

Parameter LR GEE Parameter LR GEE
β R2 p CI low–high p β R2 p CI low–high p Value
AUC Day RNFLT 0.276 0.077 <0.001 0.003 to 0.007 <0.001 TMV 0.236 0.069 0.002 0.042 to 0.176 0.001
VA 0.253 0.068 <0.001 0.073 to 0.361 0.003 VA 0.217 0.050 0.004 0.060 to 0.356 0.006
Age −0.113 0.013 0.120 −0.007 to 0.001 0.169 Age −0.093 0.008 0.213 −0.007 to 0.002 0.286
AUC Night RNFLT 0.201 0.041 0.006 0.001 to 0.009 0.007 TMV 0.188 0.049 0.012 0.034 to 0.201 0.006
VA 0.290 0.091 <0.001 0.178 to 0.624 <0.001 VA 0.264 0.075 <0.001 0.160 to 0.614 <0.001
Age −0.138 0.019 0.059 −0.011 to 0.001 0.130 Age −0.121 0.014 0.105 −0.011 to 0.002 0.186

  • Standardised β, attributable R2 change (R2) and p values from linear regressions as well as 95% CIs for (non-standardised) coefficient β and p values from GEEs are shown.

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