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Br J Ophthalmol 96:99-103 doi:10.1136/bjo.2010.194514
  • Clinical science
  • Original article

Intraocular sarcoidosis: association of clinical characteristics of uveitis with findings from 18F-labelled fluorodeoxyglucose positron emission tomography

  1. Pascal Seve4,5
  1. 1Department of Ophthalmology, Hôpital Croix-Rousse, 103 Grande Rue de la Croix-Rousse, Lyon, France
  2. 2Department of Nuclear Medicine, Hôpital Edouard Herriot, Place d'Arsonval, 69437 Lyon, France
  3. 3Laboratoire Biostatistique Santé, Centre Hospitalier Lyon-Sud, Pierre-Bénite, Lyon, France
  4. 4Department of Internal Medicine, Hôpital Croix-Rousse, 103 Grande Rue de la Croix-Rousse, 69317 Lyon Cedex 04, France
  5. 5Université Claude Bernard Lyon 1, 43 Boulevard 11 Novembre 1918, Villeurbanne, France
  1. Correspondence to Pascal Sève, Department of Internal Medicine, Hôtel Dieu, 1 place de l'Hôpital, 69288 Lyon Cedex 02, France; pascal.seve{at}chu-lyon.fr
  • Accepted 24 February 2011
  • Published Online First 3 April 2011

Abstract

Aims To assess specific clinical criteria in patients with uveitis that are related to signs of sarcoidosis on 18F-labelled fluorodeoxyglucose positron emission tomography (18F-FDG-PET).

Methods Retrospective study of 54 consecutive patients with chronic uveitis for whom a PET scan was done because of suspected sarcoidosis, between July 2004 and December 2009. All the patients underwent a clinical examination, biological tests and a high-resolution CT of the chest.

Results 17 of the 54 patients (31.5%) presented hypermetabolic foci on 18F-FDG-PET scan consistent with sarcoidosis. Among them eight patients (14.8%) underwent biopsy showing non-caseating granuloma. At the end of the study, 10 patients (18.5%) were considered as having a presumed sarcoidosis and seven patients (12.9%) as having indeterminate sarcoidosis. The increasing age at the diagnosis of uveitis (p=0.01), the presence of posterior synechiae (p=0.01) and a positive high-resolution CT of the chest (p=0.01) were significantly related to an abnormal PET scan.

Conclusions Increasing age at the diagnosis of uveitis, the presence of posterior synechiae and the positivity of high-resolution chest CT are associated with 18F-FDG PET scan signs consistent with sarcoidosis.

Footnotes

  • Study performed at Hospices Civils de Lyon, Quai des Célestins, 69288 Lyon Cedex 02, France.

  • Competing interests None

  • Ethics approval This study was conducted with the approval of the Ethical Review Board of the University of Lyon.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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    1. bjo.2010.194514v1
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