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Conjunctival and corneal ulcerations: keep a sharp eye on nicorandil
  1. P Trechot1,
  2. M C Bazard2,
  3. N Petitpain3,
  4. F Trechot2,
  5. L Javot3,
  6. K Angioi4
  1. 1Department of Clinical Pharmacology, University Hospital of Nancy, Nancy, France
  2. 2Department of Ophthalmology, University Hospital of Nancy, Nancy, France
  3. 3Regional Pharmacovigilance Center, University Hospital of Nancy, Nancy, France
  4. 4Department of Ophthalmology, University Hospital of Nancy, Vandoeuvre lès Nancy, France
  1. Correspondence to Dr Philippe Trechot, Department of Clinical Pharmacology, University Hospital of Nancy, 54035 Nancy, France; p.trechot{at}chu-nancy.fr

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Nicorandil (Adancor, Ikorel, etc) is a vasodilatator that was first used in Japan (1984) and later (1994) in European and Asian countries for the management of angina.

Nicorandil, a nicotinamide ester, is an association of nitrates and potassium channel activators, thus decreasing both cardiac preload and afterload.

Neither nitric oxide donors nor potassium channel …

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