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Br J Ophthalmol 96:1153-1154 doi:10.1136/bjophthalmol-2012-301823
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Resistance, not tachyphylaxis or tolerance

  1. Heikki Minn2
  1. 1Department of Biology, University of Turku, Finland
  2. 2Department of Oncology and Radio Therapy, Turku PET Centre, Turku University Hospital, Turku, Finland
  1. Correspondence to Dr Olli Arjamaa, Department of Biology, Vesilinnanmäki, University of Turku, Turku 20014, Finland; olli.arjamaa{at}utu.fi

  1. Contributors OA and HM made substantial contributions in designing, drafting and revising the letter. Both approved the final version to be published.

We read with great interest the editorial ‘Loss of reactivity in intravitreal anti-VEGF therapy: tachyphylaxis or tolerance?’ published recently in the British Journal of Ophthalmology.1 The editorial discussed possible mechanisms behind decreased anti-vascular endothelial growth factor (anti-VEGF) response to neovascular age-related macular degeneration (AMD). Two articles were published in the same issue in which tachyphylaxis was suggested to occur during anti-VEGF treatment of wet AMD.2 ,3 The editorial and these papers stimulated us to comment on the discussion. …

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