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VEGF Trap-Eye for CRVO: GALILEO study
Holz et al evaluated intravitreal VEGF Trap-Eye (VTE) in 177 patients with macular oedema secondary to central retinal vein occlusion (CRVO). In this double-masked study, patients were randomised (3 : 2 ratio) to intravitreal injections of VTE 2 mg or sham procedure every 4 weeks for 24 weeks. From baseline until week 24, more patients receiving VTE (60.2%) gained ≥15 letters compared with those receiving sham injections (22.1%). Mean CRT decreased by 449 µm and 169 µm in the VTE and sham groups. The most frequent ocular adverse events in the VTE arm were associated with the injection. The authors conclude that VTE provides a new treatment option for CRVO.
Effect of prophylactic laser iridotomy on corneal endothelial cell density
Kumar et al assesses the effect of prophylactic laser peripheral iridotomy (LPI) on corneal endothelial cell density (ECD) and morphology in primary angle closure suspects over 3 years. In this prospective cohort study, 230 subjects underwent LPI in one eye, while …