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Intravitreal dexamethasone for central retinal vein occlusion with low visual acuity: a retrospective study
  1. Christiana Dinah1,
  2. Kapka Nenova2,
  3. Sreekumari Pushpoth3,
  4. Ibraheem El-Ghrably3,
  5. Deepali Varma1,
  6. Stephen James Talks2
  1. 1 Sunderland Eye Infirmary, Sunderland, UK
  2. 2 Ophthalmology Department, Royal Victoria Infirmary, Newcastle upon Tyne, UK
  3. 3 James Cook University Hospital, Middlesbrough, UK
  1. Correspondence to Dr Christiana Dinah, Sunderland Eye Infirmary, Queen Alexander Road, Sunderland SR2 7SL, UK; cdinah{at}doctors.org.uk

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Introduction

The GENEVA trial1 described the efficacy and safety of dexamethasone intravitreal implant (Ozurdex, Allergan) in treatment of patients with macular oedema due to post-retinal vein occlusion (RVO). However, this trial excluded RVO patients with a baseline best-corrected visual acuity (BCVA) of less than 34 Early Treatment of Diabetes Retinopathy Study (ETDRS) letters. We conducted a study of our clinical outcomes with Ozurdex in patients with macular oedema-associated central RVO (CRVO) and identified 19 patients with a baseline BCVA less than 34 ETDRS letters.

Methods

Medical records and optical coherence tomography (OCT) images of consecutive patients with macular oedema secondary to CRVO treated with Ozurdex between October 2010 and January 2012 in three centres in the northeast part of England were reviewed. Patients were seen at baseline and 1, 3 and 6 months after injection of Ozurdex. Treatment-naive CRVO patients with at least 6 months follow-up were included. Exclusion criteria were presence of anterior or posterior segment neovascularisation and relative afferent pupillary defect. Data …

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