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Choroidal naevi complicated by choroidal neovascular membrane and outer retinal tubulation
  1. Vasilios P Papastefanou1,2,
  2. Vanda Nogueira2,
  3. Gordon Hay1,
  4. Richard M Andrews2,3,
  5. Martin Harris4,
  6. Victoria M L Cohen1,3,
  7. Mandeep S Sagoo1,2,3,5
  1. 1Ocular Oncology Service, St Bartholomew`s Hospital and Moorfields Eye Hospital, London, UK
  2. 2Medical Retina Service, Moorfields Eye Hospital, London, UK
  3. 3NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital, London, UK
  4. 4Medical Retina Service, Barnet General Hospital, Barnet, UK
  5. 5Ocular Biology & Theraputics, UCL Institute of Ophthalmology, London, UK
  1. Correspondence to Mandeep S Sagoo, Ocular Oncology Service, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK; mandeep.sagoo{at}bartshealth.nhs.uk

Abstract

Aims To present the outcomes of a series of patients with choroidal neovascular membrane (CNV) secondary to a choroidal naevus and report the presence of outer retinal tubulation.

Methods In this retrospective series, patients underwent a complete clinical and imaging assessment (fundus photo, fluorescein angiography and optical coherence tomography) and were observed or managed with intravitreal anti-VEGF injections dependent on whether visual acuity was affected.

Results Seventeen patients were included in this study. Of this, 46% (8/17) had classic or predominantly classic CNV and 53% (9/17) had occult or minimally classic CNV. Active treatment with intravitreal anti-VEGF injections was required in 35% (6/17). Visual acuity improved in three eyes by 2–4 Snellen lines, remained stable in one eye and worsened in two eyes by 2 Snellen lines. CNV partially regressed in five cases. In the observation group (65%, 11/17), visual acuity did not change during follow-up period. Outer retinal tubulation was found in 18% (3/17).

Conclusions Anti-VEGF treatment is effective in the management of vision threatening CNV secondary to a choroidal naevus. Functional or anatomical improvement was obtained in 66% of treated eyes. Outer retinal tubulation, noted in 18%, showed the clinical importance of this sign in determining continuation of anti-VEGF treatment.

  • Choroid
  • Neovascularisation
  • Neoplasia

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