Article Text

PDF
Optical aberrations in patients with recurrent herpes simplex keratitis and apparently normal vision
  1. Godefroy Kaswin1,
  2. Antoine Rousseau1,
  3. Mohamed M'Garrech1,
  4. Emmanuel Barreau1,
  5. Nicolas Pogorzalek1,
  6. Ivan De Monchy1,
  7. Richard Legras2,
  8. Marc Labetoulle1,3
  1. 1Service d'Ophtalmologie, Hôpital Bicêtre, APHP, Université Paris Sud, Le Kremlin-Bicêtre, France
  2. 2Laboratoire Aimé Cotton, UPR 3321, CNRS Orsay, Université Paris Sud, Orsay, France
  3. 3Laboratoire de Virologie Moléculaire et Structurale, UPR 3296, CNRS Gif-sur-Yvette, France
  1. Correspondence to Professor Marc Labetoulle, Service d'Ophtalmologie, Hopital Bicêtre, APHP, Université Paris Sud, Le Kremlin-Bicêtre 94275, France; marc.labetoulle{at}bct.aphp.fr

Abstract

Aims To analyse high-order aberrations (HOA), modulation transfer function (MTF) and Strehl ratio in patients with a history of herpes simplex keratitis (HSK) and apparently normal vision.

Methods Fifteen patients with a history of recurrent unilateral HSK and normal Snellen visual acuity (0 logMAR) were enrolled. Eyes with HSK (HSK group) were statistically compared with normal fellow eyes (Control group). HOA, MTF and Strehl ratio were measured using the OPD-SCAN II (Nidek Co, Gamagori, Japan) aberrometer. Measures were performed at least 3 months after the last episode of herpes. Statistical significance was indicated by p<0.05.

Results Despite apparently normal vision in both eyes (as assessed by routine visual acuity charts), significantly higher total HOA, trefoil and tetrafoil were present in the HSK group compared with the Control group. The MTF and strehl ratio were lower in the HSK group compared with the Control group. In the HSK group, eyes with corneal opacities tended to present with greater optical aberrations than eyes with a clear cornea.

Conclusions Using patients as their own controls, the outcomes of this study indicate that eyes with recurrent HSK with no apparent decrease in visual acuity (0 logMAR) have significantly greater optical aberrations than eyes with no past history of herpetic disease. This outcome may explain some visual complaints of HSK patients, such as a decrease in contrast quality or reduced colour perception, compared with the unaffected contralateral eye despite apparently normal vision in both eyes.

  • Cornea
  • Infection
  • Optics and Refraction

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.