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Risk of retinal vein occlusion in patients with systemic lupus erythematosus: a population-based cohort study
  1. Yung-Chang Yen1,2,
  2. Shih-Feng Weng3,4,
  3. Horng-An Chen5,
  4. Yung-Song Lin6,7
  1. 1Department of Ophthalmology, Chi Mei Medical Centre, Liou-Ying Campus, Tainan City, Taiwan
  2. 2Department of Nursing, Min Hwei College of Health Care Management, Liou-Ying Campus, Tainan City, Taiwan
  3. 3Department of Medical Research, Chi Mei Medical Centre, Yung-Kang District, Tainan City, Taiwan
  4. 4Department of Hospital and Health Care Administration, Chia-Nan University of Pharmacy and Science, Ren De District, Tainan City, Taiwan
  5. 5Department of Rheumatology, Chi Mei Medical Centre, Yung-Kang District, Tainan City, Taiwan
  6. 6Department of Otolaryngology, School of Medicine, Taipei Medical University, Taipei, Taiwan
  7. 7Department of Otolaryngology, Chi Mei Medical Centre, Yung-Kang District, Tainan City, Taiwan
  1. Correspondence to Professor Yung-Song Lin, Department of Otolaryngology, School of Medicine, Taipei Medical University, 250 Wu-Xing Street, Xinyi District, Taipei City 110, Taiwan; kingear{at}gmail.com

Abstract

Background/aims To investigate the risk of developing retinal vein occlusion (RVO) in patients with systemic lupus erythematosus (SLE).

Methods In this retrospective population-based cohort study, 6756 patients with SLE and 40 536 controls without SLE (1:6) were selected from the Taiwan National Health Insurance Research Database claims from 2001 to 2006.

Results The incidence of RVO was 3.46-times higher in the SLE group than in controls (5.61 vs 1.62 per 10 000 person-years) (adjusted HR=3.883, 95% CI 2.299 to 6.558) calculated using Cox proportional hazard regression. Age was an independent risk factor for RVO, with adjusted HRs of 4.842 for individuals aged ≥50 years compared with those 0–49 years. For each age subgroup, the risk of RVO was significantly higher only in the 0–49-year-old SLE group than in controls. In the 0–49-year-old SLE group the incidence of developing RVO was 7.92 times higher (95% CI 3.60 to 17.45) in the SLE group than in the 0–49-year-old controls. In women with SLE, the incidence of developing RVO was 3.33-times higher (95% CI 1.88 to 5.90) than in female controls.

Conclusions SLE was significantly associated with an increased risk of developing RVO.

  • Epidemiology
  • Retina

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