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Retinal haemorrhage, subretinal pigment epithelial deposits and serous macular detachment in light chain deposition disease
  1. Simon D Kolb1,
  2. Narendra Dhingra2,
  3. Martin A McKibbin1
  1. 1 Department of Ophthalmology, St. James's University Hospital, Leeds, UK
  2. 2 Department of Ophthalmology, Mid-Yorkshire Hospitals NHS Trust, Wakefield, UK
  1. Correspondence to Dr Simon D Kolb, Department of Ophthalmology, St. James's University Hospital, Beckett Street, Leeds, West Yorkshire LS9 7TF, UK; simonkolb{at}doctors.org.uk

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Light chain deposition disease (LCDD) is a rare form of monoclonal gammopathy, characterised by deposits of either kappa or gamma light chains (LC) most frequently in the kidney, causing renal failure.1 LCDD is diagnosed by immunohistochemistry and transmission electron microscopy of renal biopsies.2 The frequency of ocular disease is not known (personal communication, National Amyloidosis Centre, University College London). Retinal vasculopathy such as hyperviscosity syndrome has previously been reported in association with LCDD.3 ,4 A recent case series of three patients with LCDD described retinal pigment epithelial (RPE) detachments and tears with subsequent retinal haemorrhage, fibrosis and degeneration due to LC deposition.5 We present a patient with subretinal haemorrhage and serous macular detachment secondary to choroidal neovascularisation but without pigment epithelial detachment …

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