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Weight at first detection of retinopathy of prematurity predicts disease severity
  1. Pia Lundgren1,
  2. Åsa Wilde1,
  3. Chatarina Löfqvist1,
  4. Lois E H Smith2,
  5. Anna-Lena Hård1,
  6. Ann Hellström1
  1. 1Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
  2. 2Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA
  1. Correspondence to Dr Pia Lundgren, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg 416 85, Sweden; pia.lundgren{at}gu.se

Abstract

Objective To investigate whether postnatal weight at first detection of retinopathy of prematurity (ROP) can predict preterm infants who will develop severe ROP warranting treatment.

Design This modern, population-based cohort included 147 infants born at gestational age (GA) <32 weeks in the Gothenburg region during 2011–2012 and screened for ROP at Sahlgrenska University hospital. GA, birth weight (BW), and weekly postnatal weight from birth until postmenstrual age (PMA) 40 weeks data were retrospectively retrieved. Birth weight SD scores (BWSDS) were calculated. ROP data, including first detected ROP stage, maximal ROP stage, ROP treatment, and PMA at first detected sign of ROP were also retrieved. Weight SDS (WSDS) at first ROP detection was calculated.

Results Stepwise multivariate logistic regression analysis revealed that the best fit-model of risk factors for developing severe ROP warranting treatment included; GA (OR=0.28, CI 95% 0.12 to 0.66, p<0.01) and WSDS at first ROP detection (OR=0.22, CI 95% 0.05 to 0.89, p<0.05).

Conclusions Low weight and low WSDS at first ROP detection can be useful predictors for ROP warranting treatment.

  • Retina

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