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Retinal oxygen metabolism in healthy subjects and glaucoma patients
  1. Olof Birna Olafsdottir1,
  2. Evelien Vandewalle2,3,
  3. Luis Abegão Pinto4,
  4. Asbjorg Geirsdottir1,5,
  5. Eline De Clerck3,
  6. Peter Stalmans3,
  7. Maria Soffia Gottfredsdottir5,
  8. Jona Valgerdur Kristjansdottir5,
  9. Joachim Van Calster3,
  10. Thierry Zeyen3,
  11. Einar Stefánsson1,5,
  12. Ingeborg Stalmans2,3
  1. 1Department of Ophthalmology, University of Iceland, Reykjavik, Iceland
  2. 2Department of Ophthalmology Neurosciences, Laboratory of Ophthalmology, Katholieke Universiteit Leuven, Leuven, Belgium
  3. 3Department of Ophthalmology, University Hospitals Leuven, Leuven, Belgium
  4. 4Faculty of Medicine, Department of Pharmacology and Neurosciences, Lisbon University, Lisbon, Portugal
  5. 5Department of Ophthalmology, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland
  1. Correspondence to Professor I Stalmans, Department of Ophthalmology, University Hospitals Leuven, Campus St Raphaël, Kapucijnenvoer 33, Leuven B-3000, Belgium; ingeborg.stalmans{at}uzleuven.be

Abstract

Background To test whether retinal oxygen metabolism is different in glaucoma patients compared with healthy subjects.

Methods This was a two-centre study where retinal vessel oxygen saturation was measured in glaucoma patients and healthy individuals with a non-invasive spectrophotometric retinal oximeter. Visual fields were obtained in the glaucoma patients.

Results No statistical difference was found in retinal oxygen saturation in arterioles (p=0.16), venules (p=0.16) and arteriovenous difference (p=0.24) when all glaucoma patients (n=74) were compared with healthy individuals (n=89). When patients with advanced glaucoma (visual field mean defect (MD ≥ 10 dB, n=21)) were compared with healthy individuals, the oxygen saturation in venules was higher in glaucoma patients (58.2%±5.4% vs 53.8%±6.4%; p=0.0054, mean±SD) and the arteriovenous difference was lower in glaucoma patients (36.4%±4.7% vs 39.5%±5.7%; p=0.021). In glaucoma patients with mild glaucoma (visual field MD ≤ 5 dB, n=33), no statistical differences were found in retinal oxygen saturation compared with healthy individuals.

Conclusions Glaucoma patients with advanced glaucoma have higher oxygen saturation in venules and lower arteriovenous difference in oxygen saturation compared with healthy individuals. The decreased arteriovenous difference in severe glaucoma may be related to lower oxygen consumption secondary to neuropathy.

  • Glaucoma
  • Imaging
  • Physiology
  • Retina

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