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Ophthalmic manifestations of perinatally acquired HIV in a US cohort of long-term survivors
  1. Tina Rutar1,2,
  2. Jiwon Youm3,
  3. Travis Porco1,4,5,
  4. Nicole Tilton2,
  5. Mica Muskat2,
  6. Nancy McNamara1,4,
  7. Diane Wara2
  1. 1Department of Ophthalmology, University of California San Francisco, San Francisco, California, USA
  2. 2Department of Pediatrics, University of California San Francisco, San Francisco, California, USA
  3. 3University of California San Francisco School of Medicine, San Francisco, California, USA
  4. 4Francis I. Proctor Institute for Research in Ophthalmology, University of California San Francisco, San Francisco, California, USA
  5. 5Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA
  1. Correspondence to Dr Tina Rutar, Cataract and Laser Institute, 1408 E. Barnett Rd., Medford, OR 97504, USA; trutar{at}medfordeyedoctors.com

Abstract

Background/aims To determine the ophthalmic manifestations of HIV in a cohort of long-term survivors of perinatally acquired HIV.

Methods Twenty-two patients with perinatally acquired HIV who were aged ≥12 years were prospectively studied at a university clinic. They underwent complete ophthalmic examinations and fundus photography. Their medical histories, medications and CD4 counts were abstracted from the medical records. To evaluate for keratoconjunctivitis sicca, both HIV patients and 44 healthy controls (matched by age, gender and contact lens wear) underwent Schirmer testing and ocular surface staining.

Results Nine male and 13 female HIV patients with mean age of 16.6 years (SD, 3.4) were examined. Of the 22 HIV patients, 21 had been treated with highly active antiretroviral therapy (HAART). Only one patient had a CD4 count nadir of <200 cells/µL. The mean visual acuity of the eyes of the HIV subjects was 20/22 (SD, 1.6 lines). No patient had cytomegalovirus retinitis. Four of the 22 (18%) HIV patients had strabismus. HIV subjects and controls had similar rates of abnormal Schirmer (9% and 14%, p=0.62) and ocular staining scores (p=0.29).

Conclusions In the post-HAART era, long-term survivors of perinatally acquired HIV exhibited little vision-threatening disease, but had a high prevalence of strabismus.

  • Child health (paediatrics)
  • Infection

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