Article Text

other Versions

Influence of three-piece and single-piece designs of two sharp-edge optic hydrophobic acrylic intraocular lenses on prevention of posterior capsule opacification: A prospective randomised long-term clinical trial
  1. Reda Zemaitiene (reda.zemaitiene{at},
  2. Vytautas Jasinskas (vytautas.jasinskas{at},
  3. Gerd U Auffarth (auffarthg{at}
  1. Eye Clinic of Kaunas University of Medicine, Lithuania
  2. Eye Clinic of Kaunas University of Medicine, Lithuania
  3. Dept. of Ophthalmology, Ruprecht-Karls-University of Heidelberg, Germany


    Background: Posterior capsule opacification (PCO) is still a major long-term complication of modern cataract surgery. We evaluated the impact of sharp-edged intraocular lenses (IOL) of different haptic design made from the same hydrophobic acrylic material on posterior and anterior lens capsule opacification. Setting: Eye clinic of Kaunas University of Medicine, Lithuania: Prospective randomised clinical study.

    Methods: Seventy four eyes of 74 patients scheduled for cataract surgery were included in a prospective randomized clinical study. Thirty seven eyes of 37 patients received a 3-piece acrylic hydrophobic (AcrySof, MA3OBA, Alcon) IOL and 37 eyes of 37 patients- 1-piece acrylic hydrophobic (AcrySof, SA3OAL, Alcon) IOL. Visual acuity, anterior capsule opacification (ACO), capsular folds, capsulorrhexis/optic overlapping and posterior capsule opacification (PCO) were evaluated. ACO was assessed subjectively. PCO values in the entire IOL optic area and in the central 3-mm optic zone were assessed using a photographic image-analysis system (EPCO2000). Follow ups were performed postoperatively at 1 day, 6 months, 1 year and 2 years.

    Results: There were no significant differences in best corrected visual acuity, grade of ACO and capsulorrhexis/optic overlapping between IOL types during the follow-up period. Patients in 1-piece acrylic hydrophobic IOL group presented more frequently than the 3-piece IOL group with capsular folds behind the IOL optic area. In the 3-piece acrylic hydrophobic IOL group PCO values of the entire IOL optic area were significantly lower six months post-OP (3-piece: 0.002±0.009; 1-piece: 0.007±0.017; P=0.04), one year post-OP (3-piece: 0.004±0.016; 1-piece: 0.026 ±0.041; P=0.001) as well as one year post-OP in the central 3-mm optic zone (3-piece: 0.000±0.0002; 1-piece: 0.019 ±0.049; P=0.001). However, two years post-OP, PCO values in both groups did not show significant differences (entire IOL optic area: 3-piece: 0.136±0.223; 1-piece: 0.154 ±0.190; P=0.18; central zone: 3-piece: 0.023±0.065; 1-piece: 0.020±0.039; P=0.44).

    Conclusion: Long-term (2-years) follow-up after cataract surgery has shown no difference in ACO and PCO development between 3-piece and 1-piece acrylic hydrophobic intraocular lenses.

    • hydrophobic acrylic
    • intraocular lens
    • posterior capsule opacification
    • single-piece
    • three-piece

    Statistics from

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.