Background/aims: To evaluate whether aqueous humor levels of pigment epithelium-derived factor (PEDF) are associated with monocyte chemoattractant protein-1 (MCP-1) in uveitis patients.
Methods: Aqueous humor levels of MCP-1 and PEDF were determined by ELISA in 34 uveitis samples and 9 cataract control samples.
Results: Aqueous humor MCP-1 and PEDF levels were significantly higher in infectious or non-infectious uveitis patients than in controls (32.3±10.7 ng/ml vs 4.48±1.10 ng/ml vs 0.47±0.10 ng/ml and 8.40 ±1.30 μg/ml vs 5.01±0.92 μg/ml vs 1.32±0.22 μg/ml, respectively, P<0.001). A positive correlation between PEDF and MCP-1 was found in patients with uveitis (r=0.39, P<0.01).
Conclusion: The results demonstrated that aqueous humor levels of PEDF were positively associated with MCP- 1 in patients with uveitis. Our present observations suggest that aqueous humor levels of PEDF may be a marker of inflammation in uveitis.
- aqueous humor