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Br J Ophthalmol doi:10.1136/bjo.2006.109843

Positive correlation between pigment epithelium-derived factor (PEDF) and monocyte chemoattractant protein-1 (MCP-1) levels in aqueous humor of patients with uveitis

  1. Yumiko Yoshida (shoichi{at}med.kurume-u.ac.jp),
  2. Sho-ichi Yamagishi (shoichi{at}med.kurume-u.ac.jp),
  3. Takanori Matsui (shoichi{at}med.kurume-u.ac.jp),
  4. Kazuo Nakamura (shoichi{at}med.kurume-u.ac.jp),
  5. Tsutomu Imaizumi (shoichi{at}med.kurume-u.ac.jp),
  6. Koichi Yoshimura (shoichi{at}med.kurume-u.ac.jp),
  7. Ryoji Yamakawa (shoichi{at}med.kurume-u.ac.jp)
  1. kurume University, Japan
  2. Kurume University, Japan
  3. Kurume University, Japan
  4. Kurume University, Japan
  5. Kurume University, Japan
  6. Kurume University, Japan
  7. Kurume University, Japan
    • Published Online First 13 December 2006

    Abstract

    Background/aims: To evaluate whether aqueous humor levels of pigment epithelium-derived factor (PEDF) are associated with monocyte chemoattractant protein-1 (MCP-1) in uveitis patients.

    Methods: Aqueous humor levels of MCP-1 and PEDF were determined by ELISA in 34 uveitis samples and 9 cataract control samples.

    Results: Aqueous humor MCP-1 and PEDF levels were significantly higher in infectious or non-infectious uveitis patients than in controls (32.3±10.7 ng/ml vs 4.48±1.10 ng/ml vs 0.47±0.10 ng/ml and 8.40 ±1.30 μg/ml vs 5.01±0.92 μg/ml vs 1.32±0.22 μg/ml, respectively, P<0.001). A positive correlation between PEDF and MCP-1 was found in patients with uveitis (r=0.39, P<0.01).

    Conclusion: The results demonstrated that aqueous humor levels of PEDF were positively associated with MCP- 1 in patients with uveitis. Our present observations suggest that aqueous humor levels of PEDF may be a marker of inflammation in uveitis.

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