Background: To document the prevalence of refractive errors in patients with neurofibromatosis type-1 (NF1) and type-2 (NF2) and to compare with that of age and sex matched controls.
Methods: Eighty-two patients with NF1, 21 patients with NF2 and 103 age and sex matched controls were evaluated in this prospective observational case-control study. Cycloplegic autorefraction, and detailed dilated fundus examination were performed. Myopia was defined as the spherical equivalent (SE) refraction of at least -0.50 diopters (D), hyperopia as the SE refraction of at least 2.0 D, and astigmatism as cylinder of at least 1.0 D. Main outcome measures were refractive error, intelligence quotient (IQ), years of education, height, weight and body mass index (BMI).
Results: The prevalence of myopia was 23.1% in NF1 patients, 23.8% in NF2 patients and 16.5% in age and sex matched controls. These differences were statistically significant (p<0.03, p<0.03) and adjusting for intelligence, education, height, weight and BMI increased the significance of this finding (p<0.001, p<0.001). The prevalences of astigmatism and hyperopia were similar in both groups.
Conclusion: A high prevalence of myopia seems to be an additional feature of NF1 and NF2.
- Neurofibromatosis type-1,
- Neurofibromatosis type-2,
- refractive errors,