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The North Jutland County Diabetic Retinopathy Study (NCDRS). 2 Non-ophthalmic parameters and clinically significant macular oedema.
  1. Lars Loumann Knudsen (u19204{at},
  2. Hans-Henrik Lervang,
  3. Søren Lundbye-Christensen,
  4. Anders Gorst-Rasmussen
  1. Department of Ophthalmology, Aalborg Sygehus Syd, Denmark, Denmark
  2. Department of medical endocrinology, Aalborg Sygehus South, Denmark
  3. Department of Mathematical Sciences, Aalborg University, Denmark
  4. Department of Mathematical sciences, Aalborg University, Denmark


    Background: The influence of non-ophthalmic parameters on the prevalence of clinically significant macular oedema has not been unambiguously established. The present study was initiated with the aim of clarification.

    Methods: This cross-sectional study comprised 656 type 1 and 328 type 2 diabetic subjects undergoing retinopathy screening in the county of North Jutland. The association between the presence of clinically significant macular oedema and blood-pressure, HbA1c, BMI, age, onset of diabetes, duration of diabetes, blood pressure reducing medication, lipid lowering medication, neuropathy, and urinary albumin excretion was explored using multiple logistic regression analysis.

    Findings: We found no significant association between the presence of clinically significant macular oedema and any of the examined parameters in type 1 diabetic subjects. In type 2 diabetic subjects the duration of diabetes, HbA1c, neuropathy, and increased urinary albumin excretion was significantly associated to the presence of clinically significant macular oedema.

    Interpretation: The risk factors for clinically significant macular oedema differ in type 1 and type 2 diabetic subjects and can only in part account for this manifestation.

    • Diabetes
    • Diabetic maculopathy
    • Diabetic retinopathy
    • Macular oedema

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