Background: The influence of non-ophthalmic parameters on the prevalence of clinically significant macular oedema has not been unambiguously established. The present study was initiated with the aim of clarification.
Methods: This cross-sectional study comprised 656 type 1 and 328 type 2 diabetic subjects undergoing retinopathy screening in the county of North Jutland. The association between the presence of clinically significant macular oedema and blood-pressure, HbA1c, BMI, age, onset of diabetes, duration of diabetes, blood pressure reducing medication, lipid lowering medication, neuropathy, and urinary albumin excretion was explored using multiple logistic regression analysis.
Findings: We found no significant association between the presence of clinically significant macular oedema and any of the examined parameters in type 1 diabetic subjects. In type 2 diabetic subjects the duration of diabetes, HbA1c, neuropathy, and increased urinary albumin excretion was significantly associated to the presence of clinically significant macular oedema.
Interpretation: The risk factors for clinically significant macular oedema differ in type 1 and type 2 diabetic subjects and can only in part account for this manifestation.
- Diabetic maculopathy
- Diabetic retinopathy
- Macular oedema