The North Jutland County Diabetic Retinopathy Study (NCDRS). 2 Non-ophthalmic parameters and clinically significant macular oedema.
- Lars Loumann Knudsen (u19204{at}aas.nja.dk),
- Hans-Henrik Lervang,
- Søren Lundbye-Christensen,
- Anders Gorst-Rasmussen
- Department of Ophthalmology, Aalborg Sygehus Syd, Denmark, Denmark
- Department of medical endocrinology, Aalborg Sygehus South, Denmark
- Department of Mathematical Sciences, Aalborg University, Denmark
- Department of Mathematical sciences, Aalborg University, Denmark
- Published Online First 3 January 2007
Abstract
Background: The influence of non-ophthalmic parameters on the prevalence of clinically significant macular oedema has not been unambiguously established. The present study was initiated with the aim of clarification.
Methods: This cross-sectional study comprised 656 type 1 and 328 type 2 diabetic subjects undergoing retinopathy screening in the county of North Jutland. The association between the presence of clinically significant macular oedema and blood-pressure, HbA1c, BMI, age, onset of diabetes, duration of diabetes, blood pressure reducing medication, lipid lowering medication, neuropathy, and urinary albumin excretion was explored using multiple logistic regression analysis.
Findings: We found no significant association between the presence of clinically significant macular oedema and any of the examined parameters in type 1 diabetic subjects. In type 2 diabetic subjects the duration of diabetes, HbA1c, neuropathy, and increased urinary albumin excretion was significantly associated to the presence of clinically significant macular oedema.
Interpretation: The risk factors for clinically significant macular oedema differ in type 1 and type 2 diabetic subjects and can only in part account for this manifestation.
