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Quality of life and relative importance: A comparison of time trade-off and conjoint analysis methods in patients with age-related macular degeneration
  1. Peter Aspinall (p.a.aspinall{at}sbe.hw.ac.uk),
  2. A Hill,
  3. B Dhillon (bal.dhillon{at}luht.scot.nhs.uk),
  4. A M Armbrecht (amarmbrecht{at}yahoo.co.uk),
  5. P Nelson,
  6. C Lumsden,
  7. E Farini Hudson,
  8. R Brice,
  9. A Vickers,
  10. P Buchholz
  1. Heriot=Watt University, United Kingdom
  2. Princess Alexandra Eye Pavilion, United Kingdom
  3. Princess Alexandra Eye Pavilion, United Kingdom
  4. Princess Alexandra Eye Pavilion, United Kingdom
  5. Visual Impairment Research Group, United Kingdom
  6. Visual Impairment Research Group, United Kingdom
  7. Visual Impairment Research Group, United Kingdom
  8. Adelphi Research Group, United Kingdom
  9. Adelphi Research Group, United Kingdom
  10. Allergan Europe, United Kingdom

    Abstract

    Aims: To investigate relative priorities in quality of life (QoL) in patients with age related macular degeneration (AMD).

    Methods: Measures of visual function, quality of life (QoL) and utility associated with visual loss were obtained from 122 patients with AMD classified according to macular morphology. The two methods of utility assessment were time trade-off (TTO) and conjoint analysis (CA) which have been recommended by the United Kingdom's National Institute of Clinical Excellence (NICE) as techniques for the assessment of health care priorities.

    Results: Results show that the two methods for assessing utility are poorly related; TTO relates moderately to visual function and disease severity but CA does not. CA identified two different subgroups of patients, one with outdoor mobility and the other with reading as their main priority.

    Conclusion: Further work is needed and caution required interpreting data obtained using these methodologies for determining relative importance in vision related QoL studies.

    • Quality of Life
    • Time trade-off
    • age related macular degeneration
    • conjoint analysis
    • utilities

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