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Glutathione S-transferase M1 and T1 genetic polymorphisms are related to the risk of primary open angle glaucoma (POAG): a study in the Turkish population
  1. Mustafa Ünal (mustafaunalmd{at}gmail.com),
  2. Mehmet Güven (mgguven{at}istanbul.edu.tr),
  3. Kazým Devranoðlu (kdevranoglu{at}superonline.com),
  4. Ahmet Özaydin,
  5. Bahadýr Batar (bbatar{at}istanbul.edu.tr),
  6. Ebru Eroðlu Görgün (eeroglu{at}superonline.com),
  7. Didar Uçar (ducar{at}istanbul.edu.tr),
  8. Ahmet Sarýcý (asarici{at}gmail.com)
  1. Akdeniz University Medical Faculty, Turkey
  2. Department of Medical Biology, Cerrahpasa Faculty of Medicine, University of Istanbul, Istanbul, Turkey
  3. Department of Ophthalmology, Cerrahpasa Faculty of Medicine, University of Istanbul, Istanbul, Turkey
  4. Department of Medical Biology, Cerrahpasa Faculty of Medicine, University of Istanbul, Istanbul, Turkey
  5. Department of Medical Biology, Cerrahpasa Faculty of Medicine, University of Istanbul, Istanbul, Turkey
  6. Department of Ophthalmology, Cerrahpasa Faculty of Medicine, University of Istanbul, Istanbul, Turkey
  7. Department of Ophthalmology, Cerrahpasa Faculty of Medicine, University of Istanbul, Istanbul, Turkey
  8. Department of Ophthalmology, Cerrahpasa Faculty of Medicine, University of Istanbul, Istanbul, Turkey

    Abstract

    Background/aims: Genetic factors and oxidative damage have been shown to have some role in the development of primary open angle glaucoma (POAG). In this study, we aimed to determine the effects of genetic polymorphisms of glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) on risk of POAG in a Turkish population.

    Methods: Using a multiplex polymerase chain reaction (PCR), GSTM1 and GSTT1 gene polymorphisms were analysed in 144 patients with primary open angle glaucoma (POAG) and in 121 otherwise healthy control group of similar age.

    Results: The GSTM1 positive genotype and the GSTT1 null genotype had an increased risk of developing POAG (OR: 2.93, CI 95%: 1.66-5.20 and OR: 4.25, CI 95%: 2.30-7.80 respectively). The risk of glaucoma also statistically significantly increased in subjects with combination of GSTM1 positive and GSTT1 null genotypes (OR: 3.46, CI 95%: 1.64-7.38).

    Conclusion: The GSTM1 positive genotype and GSTT1 null genotype or the combination of both may be associated with increased risk of development of POAG in Turkish population.

    • Glutathione S-transferase, polymorphism, primary open angle glaucoma.

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