rss
Br J Ophthalmol doi:10.1136/bjo.2006.111534

Decreased OCT-measured pericentral retinal thickness in patients with diabetes mellitus type 1 with minimal diabetic retinopathy

  1. Carine Biallosterski (c.biallosterski{at}amc.uva.nl),
  2. Mirjam EJ van Velthoven (m.e.vanvelthoven{at}amc.uva.nl),
  3. Robert PJ Michels (r.p.michels{at}amc.uva.nl),
  4. Reinier O Schlingemann (r.schlingemann{at}amc.uva.nl),
  5. J Hans DeVries (j.h.devries{at}amc.uva.nl),
  6. Frank D Verbraak (f.d.verbraak{at}amc.uva.nl)
  1. Academic Medical Centre, Netherlands
  2. Academic Medical Centre, Netherlands
  3. Academic Medical Centre, Netherlands
  4. Academic Medical Centre, Netherlands
  5. Academic Medical Centre, Netherlands
  6. Academic Medical Centre, Netherlands
    • Published Online First 23 March 2007

    Abstract

    Aim: A comparison of retinal thickness (RT) measurements with optical coherence tomography (OCT) in patients with type 1 diabetes mellitus (DM) and no or minimal diabetic retinopathy (DR) versus healthy controls.

    Methods: Fifty-three patients with type 1 DM with no or minimal DR underwent full ophthalmic examination, fundus photography and OCT. Mean RT measured by OCT was calculated for the central fovea, the fovea, the pericentral, and the peripheral area of the macula and compared to normal controls.

    Results: Mean RT in the pericentral area was lower in patients with minimal DR (267μm ± 20μm; n=23) compared to healthy subjects (281μm ± 13μm; P value = 0.005; n=28). Mean pericentral RT in patients without DR (276μm ± 14μm; n=30) was less than pericentral RT in normal controls, but higher than in patients with minimal DR, without being statistically significant. None of the other regions showed a significant change.

    Conclusion: In this study a significantly decreased pericentral RT was measured in patients with minimal DR compared to healthy controls. This could be explained by a loss of intraretinal neural tissue in the earliest stage of DR.

    Relevant Article

    • BJO at a glance:BJO at a glance
      • Creig Hoyt
      Br J Ophthalmol 2007;91:1099

    This Article

    1. Abstract
    2. PDF
    3. All versions of this article:
      1. bjo.2006.111534v1
      2. 91/9/1135most recent

    Responses

    1. Submit a response
    2. No responses published

    Register for free content

    The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.

    Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.