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Positive correlation of pigment epithelium-derived factor (PEDF) and total anti-oxidant capacity in aqueous humor of patients with uveitis and proliferative diabetic retinopathy
  1. Yumiko Yoshida (shoichi{at}med.kurume-u.ac.jp),
  2. Sho-ichi Yamagishi (shoichi{at}med.kurume-u.ac.jp),
  3. Takanori Matsui (shoichi{at}med.kurume-u.ac.jp),
  4. Kazuo Nakamura (shoichi{at}med.kurume-u.ac.jp),
  5. Tsutomu Imaizumi (shoichi{at}med.kurume-u.ac.jp),
  6. Koichi Yoshimura (shoichi{at}med.kurume-u.ac.jp),
  7. Ryoji Yamakawa (shoichi{at}med.kurume-u.ac.jp)
  1. Kurume University, Japan
  2. Kurume University, Japan
  3. Kurume University, Japan
  4. Kurume University, Japan
  5. Kurume University, Japan
  6. Kurume University, Japan
  7. Kurume University, Japan

    Abstract

    Background/aims: There are several animal studies to suggest that pigment epithelium-derived factor (PEDF) may exert beneficial effects on diabetic retinopathy and uveitis by acting as an endogenous anti-oxidant. However, the interrelationship between PEDF and total anti-oxidant capacity in the human eye remains to be elucidated. In this study, we determined PEDF and total anti-oxidant levels in aqueous humor of patients with proliferative diabetic retinopathy (PDR) and uveitis, and investigated the relationship between these two markers.

    Methods: Aqueous humor levels of PEDF and total anti-oxidant capacity were determined by an ELISA system in 34 uveitis and 9 PDR samples.

    Results: Aqueous humor levels of PEDF and total anti-oxidant capacity were significantly lower in PDR patients than those in uveitis patients (1.8±0.2 μg/ml vs 6.4±0.8 μg/ml and 0.17±0.03 mmol/l vs 0.85±0.05 mmol/l, respectively, P<.01). A positive correlation between PEDF and total anti-oxidant capacity was found in patients with PDR and uveitis (r=.33, P<.05).

    Conclusion: This study demonstrated that PEDF levels were associated with total anti-oxidant capacity in aqueous humor levels in humans. Our present observations suggest that substitution of PEDF may be a therapeutic target for oxidative stress-involved eye diseases, especially PDR.

    • PEDF
    • anti-oxidant capacity
    • aqueous humor
    • diabetic retinopathy
    • uveitis

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