Aim: The efficacy and safety of repeated injections of intravitreal triamcinolone (IVTA) for diabetic macular oedema is unclear, with results of previous reports conflicting.
Methods: This is a prospective, observational case series of 27 eyes receiving IVTA for diabetic macular oedema. LogMAR visual acuity (VA) and central macular thickness (CMT) were measured at baseline and in 3 to 6 monthly intervals for up to 24 months, then correlated with the number of IVTA injections given.
Results: One IVTA injection was required in 6 (18%) eyes, 2 in 8 (24%) eyes, 3 in 13 (39%) eyes and 4- 5 in 6 (18%) eyes. VA improved in all patients, but neither the final improvement in VA nor the absolute improvement in CMT from baseline to 24 months correlated with the number of injections received (p=0.44 and 0.84 respectively). Cataract surgery was more frequent in eyes receiving more injections (p=0.01).
Conclusions: This study suggests that repeated injections of IVTA continue to be as effective as the first over a 2 year period. The probability of cataract surgery increases with increasing number of injections
- Diabetic retinopathy
- Intravitreal therapy
- Macular edema
- Triamcinolone Acetonide
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