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Efficacy of Intravitreal bevacizumab for polypoidal choroidal vasculopathy
  1. Fumi Gomi (fgomi{at}ophthal.med.osaka-u.ac.jp),
  2. Miki Sawa,
  3. Hirokazu Sakaguchi,
  4. Motokazu Tsujikawa,
  5. Yusuke Oshima,
  6. Motohiro Kamei,
  7. Yasuo Tano
  1. Osaka University Medical School, Japan
  2. Osaka University Medical School, Japan
  3. Osaka University Medical School, Japan
  4. Osaka University Medical School, Japan
  5. Osaka University Medical School, Japan
  6. Osaka University Medical School, Japan
  7. Osaka University Medical School, Japan

    Abstract

    Aims: To assess the short-term efficacy of intravitreal injections of bevacizumab for polypoidal choroidal vasculopathy (PCV).

    Methods: Intravitreal bevacizumab (1 mg) was injected into 11 eyes of 11 patients with PCV in this retrospective, interventional case series. The main outcome measure was the change in the polypoidal vessels on indocyanine green angiography (IA) 3 months after injection. The foveal height determined by optical coherence tomography and the best-corrected visual acuity (BCVA) also were evaluated before and after treatment.

    Results: At baseline, subretinal fluid was observed in five eyes and a pigment epithelial detachment in eight eyes. The foveal height 1 month after injection decreased significantly (p=0.023), but at 3 months, no significant decrease was observed, although an additional injection was performed in five of 11 eyes. The IA at month 3 showed resolution of polyps in one eye but residual or enlarged lesions in the other 10 eyes. The BCVA did not improve significantly, although the subjects had relatively good BCVA at baseline (mean, 0.45).

    Conclusion: Intravitreal injection of bevacizumab may reduce the fluid from PCV but seems to be ineffective for diminishing its choroidal vascular changes.

    • bevacizumab
    • choroidal neovascularization
    • choroidal vascular changes
    • polypoidal choroidal vasculopathy
    • vascular endothelial growth factor

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