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Aqueous humor levels of asymmetric dimethylarginine (ADMA) are positively associated with monocyte chemoattractant protein-1 (MCP-1) in patients with uveitis
  1. Yumiko Yoshida (shoichi{at}med.kurume-u.ac.jp),
  2. Sho-ichi Yamagishi (shoichi{at}med.kurume-u.ac.jp),
  3. Seiji Ueda (shoichi{at}med.kurume-u.ac.jp),
  4. Koichi Yoshimura (shoichi{at}med.kurume-u.ac.jp),
  5. Seiya Okuda (shoichi{at}med.kurume-u.ac.jp),
  6. Ryoji Yamakawa (shoichi{at}med.kurume-u.ac.jp)
  1. Kurume University, Japan
  2. Kurume University, Japan
  3. Kurume University, Japan
  4. Kurume University, Japan
  5. Kurume University, Japan
  6. Kurume University, Japan

    Abstract

    Background/aims: To evaluate whether aqueous humor levels of asymmetric dimethylarginine (ADMA) are associated with monocyte chemoattractant protein-1 (MCP-1).

    Methods: Aqueous humor levels of ADMA and MCP-1 were measured by HPLC and ELISA, respectively in 31 uveitis samples and 9 cataract control samples.

    Results: Aqueous humor ADMA and MCP-1 levels were significantly higher in infectious or non-infectious uveitis patients than in controls (0.67±0.04 nmol/ml vs 0.55 ±0.03 nmol/ml vs 0.43±0. 04 nmol/ml (P<0.01) and 29.0±11.3 ng/ml vs 4.5±1.2 ng/ml vs 0.47 ±0.1 ng/ml (P<0.01), respectively). A positive correlation between ADMA and MCP-1 levels in aqueous humor was found in control and uveitis patients (r=0.33, P<0.05).

    Conclusion: The results demonstrated that aqueous humor levels of ADMA were positively associated with MCP-1 in humans. Our present observations suggest that aqueous humor levels of ADMA may be a novel biomarker of inflammation in uveitis.

    • ADMA
    • MCP-1
    • aqueous humor
    • nitric oxide
    • uveitis

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