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Longitudinal quantification of aqueous flare and cells in Vogt-Koyanagi-Harada disease
  1. Wang Fang (fangwang2004{at}126.com),
  2. Hongyan Zhou,
  3. Peizeng Yang (peizengyang{at}hotmail.com),
  4. Xiangkun Huang,
  5. Li Wang,
  6. Aize Kijlstra
  1. Zhongshan Ophthalmic Center of Sun Yat-sen University, China
  2. Zhongshan Ophthalmic Center of Sun Yat-sen University, China
  3. Zhongshan Ophthalmic Center of Sun Yat-sen University, China
  4. Zhongshan Ophthalmic Center of Sun Yat-sen University, China
  5. Zhongshan Ophthalmic Center of Sun Yat-sen University, China
  6. Eye Research Institute Maastricht, Department of Ophthalmology, University Hospital Maastricht, Maas, Netherlands

    Abstract

    Aims: To quantitatively evaluate the changes of aqueous flare and cells in eyes with Vogt-Koyanagi-Harada (VKH) disease.

    Methods: This prospective study included 35 initial-onset VKH patients (70 eyes) and 46 recurrent VKH patients (92 eyes) following immunotherapy. Aqueous flare and cells were quantified using the laser flare-cell meter before treatment, 2 weeks, 1, 3, 6 and 9 months after treatment.

    Results: Before treatment, mean aqueous flare (ph/ms) in initial-onset and recurrent VKH eyes were 8.1±4.1 vs. 43.6±20.7 (P_0.000). Following treatment, recurrent VKH eyes showed a significantly higher flare value than initial-onset VKH eyes at 2 weeks, 1, 3 and 6 months. Prior to treatment, mean cell counts (cells/0.5mm3) in initial-onset and recurrent VKH eyes were 2.0±1.9 vs. 39.4±23.1 (P=0.000). Following treatment, recurrent VKH eyes showed significantly higher cell counts than initial-onset VKH eyes at 2 weeks, 1 and 3 months.

    Conclusions: Our study shows that recurrent VKH patients displayed a more striking and long-lasting breakdown of the BAB and more severe inflammation than initial-onset VKH patients. Our study also indicates that the disruption of BAB lasted longer than aqueous cells either in initial-onset or in recurrent VKH patients.

    • Aqueous humour
    • Inflammation
    • Vogt-Koyanagi-Harada syndrome
    • laser flare-cell meter
    • uveitis

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