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Br J Ophthalmol doi:10.1136/bjo.2007.127050

HLA-DR17 and Mooren's Ulcer in South India

  1. Joseph R. Zelefsky MD (jzelefsk{at}yahoo.com),
  2. Craig J. Taylor, PhD (craig.taylor{at}addenbrookes.nhs.uk),
  3. Muthaiah Srinivasan MD (m.srinivasan{at}aravind.org),
  4. Sarah Galasinski, BSc,
  5. Reyna S. Goodman, BSc,
  6. Timothy Key, MSc,
  7. Peter G. Watson MD,
  8. Emmett T. Cunningham, Jr. (emmett_cunningham{at}yahoo.com)
  1. New York University, United States
  2. Cambridge University Hospitals NHS Foundation Trust, United Kingdom
  3. Aravind, India
  4. Cambridge University Hospitals NHS Foundation Trust, United Kingdom
  5. Cambridge University Hospitals NHS Foundation Trust, United Kingdom
  6. Cambridge University Hospitals NHS Foundation Trust, United Kingdom
  7. Cambridge University Hospitals NHS Foundation Trust, United Kingdom
  8. Francis I. Proctor Foundation, UCSF School of Medicine, United States
    • Published Online First 22 January 2008

    Abstract

    Objective: To investigate the association between Mooren's ulcer and human leukocyte antigen (HLA) type DR17(3) in patients from the Tamil Nadu State of South India .

    Methods: Blood samples from 38 patients with Mooren's ulcer and 45 age- and sex-matched controls were obtained prospectively. HLA-DR and -DQ typing was performed by polymerase chain reaction (PCR) using sequence specific primers.

    Results: Fifteen (39.5%) of the Mooren's ulcer patients tested positive for HLA-DR17(3), as compared to seven (15.6%) of the controls (p=0.01). Seventeen (44.7%) of the Mooren’s ulcer patients also tested positive for the closely linked HLA-DQ2, as compared to eleven (24.4%) of controls (p=0.05). When adjusted for multiplicity, the correlation between HLA-DR17(3) and Mooren's ulcer remained statistically significant (p=0.03).

    Conclusions: These data demonstrate an association between HLA-DR17(3) and Mooren's ulcer in South Indian patients, supporting autoimmune theories in the pathogenesis of the disorder.

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