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Interleukin 8 promoter polymorphism -251A/T is a risk factor for age related macular degeneration.
  1. Srini V Goverdhan (sg5{at}soton.ac.uk),
  2. Sarah Ennis,
  3. S R Hannan,
  4. K C Madhusudhana,
  5. A J Cree,
  6. A J Luff,
  7. Andrew J Lotery (a.j.lotery{at}soton.ac.uk)
  1. Clinical Neurosciences Division, United Kingdom
  2. Clinical Neurosciences Division, United Kingdom
  3. Southampton Eye Unit, United Kingdom
  4. Southampton Eye Unit, United Kingdom
  5. Clinical Neurosciences Division, United Kingdom
  6. Southampton Eye Unit, United Kingdom
  7. Southampton Eye Unit, United Kingdom

    Abstract

    Background/aims: To determine whether four expression-related cytokine polymorphisms are associated with age related macular degeneration (AMD).

    Methods: DNA from 478 cases with AMD and 555 normal controls was genotyped for the pro-inflammatory IL 1β -511C/T, IL 6 -174C/G, IL 8 -251A/T and anti-inflammatory IL 10 -1082G/A cytokine polymorphisms using the 5' nuclease Taqman assay for allelic discrimination. Associations with AMD were analysed using allelic frequencies.

    Results: The -251A allele of the IL 8 promoter gene polymorphism was more prevalent in AMD patients than controls (P=0.037, OR=1.21, 95% CI=1.01-1.44). Adjusting for age, sex, body mass index (BMI), current smoking and past smoking status did not alter the AMD association significantly (PC= 0.043, OR=1.23, 95% CI=1.0 to 1.50).

    Conclusion: The pro-inflammatory homozygous IL 8 -251AA genotype is an important risk factor for AMD. This may have implications for future therapy with biological agents that could target this cytokine.

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