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Open clinical study of eyedrops containing tetrapeptides derived from substance P and IGF-1 for treatment of persistent corneal epithelial defects associated with neurotrophic keratopathy
  1. Naoyuki Yamada (n.yamada{at}po.cc.yamaguchi-u.ac.jp),
  2. Rie Matsuda,
  3. Naoyuki Morishige,
  4. Ryoji Yanai,
  5. Tai-ichiro Chikama,
  6. Teruo Nishida,
  7. Tadashi Ishimitsu,
  8. Akira Kamiya
  1. Yamaguchi University School of Medicine, Japan
  2. Department of Ophthalmology, Yamaguchi University Graduate School of Medicine,, Japan
  3. Department of Ophthalmology, Yamaguchi University Graduate School of Medicine,, Japan
  4. Department of Ophthalmology, Yamaguchi University Graduate School of Medicine,, Japan
  5. Department of Ocular Pathophysiology, Yamaguchi University School of Medicine, Japan
  6. Department of Ophthalmology, Yamaguchi University Graduate School of Medicine,, Japan
  7. Department of Pharmacy, Yamaguchi University Hospital, Japan
  8. Department of Pharmacy, Yamaguchi University Hospital, Japan

    Abstract

    Background/Aims: Loss of corneal sensation results in the development of persistent corneal epithelial defects. The combination of a substance P-derived peptide (FGLM-amide) and an insulin-like growth factor-1 (IGF-1)-derived peptide (SSSR) stimulates rabbit corneal epithelial migration in vitro and rabbit corneal epithelial wound closure in vivo. The clinical efficacy of eyedrops containing FGLM-amide and SSSR for the treatment of persistent corneal epithelial defects in individuals with neurotrophic keratopathy was examined in a prospective open study.

    Methods: Twenty-five consecutive patients (26 eyes) with persistent corneal epithelial defects associated with neurotrophic keratopathy were treated by administration of eyedrops containing FGLM-amide and SSSR. The course of epithelial healing was monitored by slitlamp examination.

    Results: Epithelial defects resurfaced completely in 19 of the 26 eyes (73%) within 4 weeks after treatment initiation. Complete resurfacing of epithelial defects was apparent in 18 of 22 (82%) or in 1 of 4 (25%) eyes without or with limbal stem cell deficiency, respectively. No adverse effects of treatment were observed in any subject.

    Conclusion: Eyedrops containing FGLM-amide and SSSR induced the rapid resurfacing of persistent epithelial defects in stem cell-positive individuals with neurotrophic keratopathy.

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