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Reduced Fluence versus Standard Photodynamic Therapy in Combination with Intravitreal Triamcinolone
  1. Stefan Sacu (stefan.sacu{at},
  2. Alina Varga,
  3. Stephan Michels,
  4. Gunther Weigert,
  5. Kaija Polak,
  6. Pia Veronika Vécsei-Marlovits,
  7. Ursula Margarethe Schmidt-erfurth ({at}
  1. Medical University of Vienna, Austria
  2. Medical University of Vienna, Austria
  3. University of Zurich, Switzerland
  4. Medical University of Vienna, Austria
  5. Medical University of Vienna, Austria
  6. Medical University of Vienna, Austria
  7. AKH 8i, Medizinische Universität Wien, Austria


    Background: To compare early treatment effect of reduced fluence versus standard photodynamic therapy (rPDT, sPDT, respectively) in combination with intravitreal triamcinolone (IVTA) in neovascular age-related macular degeneration.

    Methods: Forty patients either received sPDT (group A, n=20) or rPDT (group B, n=20) each followed by same day 4mg IVTA. Patients were examined at baseline, day 1, week 1, 4 and 12. Main outcomes were visual acuity, central retinal thickness (CRT), choroidal perfusion and the macular sensitivity (MS).

    Results: Baseline characteristics were well balanced in both groups (p>0.05). At week 12, patients in group A had a mean loss of -3.7 letters compared with a win of 3.4 letters in group B (p=0.04, between both groups). Both treatment groups showed a similar course regarding CRT as well as MS (p>0.05). In 70% (14/20) of group A and 15% (3/20) of group B a choroidal hypoperfusion in the area of treatment was observed after treatment (p<0.001). In 70% of group A and 55% of group B a retreatment was indicated at week 12 (p=0.55).

    Conclusions: Combination therapy using a rPDT+IVTA showed a significant better visual outcome less alteration of the choroid and trend for lower recurrence rate than a sPDT+IVTA at week 12.

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