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24-hour intraocular pressure and blood pressure levels with bimatoprost versus latanoprost in patients with normal-tension glaucoma
  1. Luciano Quaranta,
  2. Teodoro Pizzolante,
  3. Ivano Riva,
  4. Anna-Bettina Haidich,
  5. Anastasios GP Konstas,
  6. William C. Stewart (info{at}prnorb.com)
  1. Department of Ophthalmology, University of Brescia, Italy
  2. Department of Ophthalmology, University of Brescia, Italy
  3. Department of Ophthalmology, University of Brescia, Italy
  4. Aristotle University of Thessaloniki, Greece
  5. Department of Ophthalmology, AHEPA Hospital, Greece
  6. PRN Pharmaceutical Research Network, LLC, United States

    Abstract

    Purpose: To evaluate 24-hour intraocular pressure (IOP) and blood pressure (BP) with bimatoprost or latanoprost in patients with normal-tension glaucoma.

    Design: Prospective, randomized, crossover, active-controlled, observer-masked study.

    Methods: After a 6 week medicine-free period, we randomized patients to either latanoprost or bimatoprost for 8 weeks and then to the opposite medicine for 8 weeks. At baseline, and at the end of each treatment period, we evaluated IOP and BP at 08:00 and then every 2 hours over the 24-hour day. Diastolic ocular perfusion pressure (DOPP) was calculated from the above parameters.

    Results: Forty completed patients had a 24-hour untreated baseline IOP of 15.5±2.3 mm Hg, and a DOPP of 59.2±6.1 mm Hg. Both treatments lowered IOP at each time point (P<0.006), and over the 24-hour curve (P<0.001, both medicines 13.1 mm Hg, 16% decrease). No difference existed between treatments in absolute IOP, at each time point, and over the 24-hour curve (P ≥0.26). Additionally, no differences were found between treated 24-hour systolic (P≥0.29) and diastolic BP (P≥0.12). The mean 24-hour DOPP for latanoprost was increased from baseline (3%, P=0.031) but not for bimatoprost (2%, P = 0.21). However, no difference in DOPP existed between treatments at any time point or over the 24 hour curve (P≥0.17). No difference was observed between treatments for any adverse event (P>0.05).

    Conclusions: In patients with normal-tension glaucoma both bimatoprost and latanoprost reduce the 24-hour intraocular pressure from untreated baseline to a similar extent. Latanoprost is associated with slightly improved ocular diastolic perfusion pressure over 24 hours.

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