Article Text

other Versions

PDF
Clinical manifestations and treatment of retinoblastoma in Korea
  1. Song Ee Chung (songee129{at}hanmail.net),
  2. Ho Seok Sa (lineblue{at}hanmail.net),
  3. Hong Hoe Koo (hhkoo.koo{at}samsung.com),
  4. Keon Hee Yoo (keonhee.yoo{at}samsung.com),
  5. Ki Woong Sung (kwsped{at}skku.edu),
  6. Don-Il Ham (oculus{at}naver.com)
  1. Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan Univ, Korea, Republic of
  2. Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan Univ, Korea, Republic of
  3. Department of Pediatrics, Samsung Medical Center, Korea, Republic of
  4. Department of Pediatrics, Samsung Medical Center, Korea, Republic of
  5. Department of Pediatrics, Samsung Medical Center, Sungkyunkwan Univ, Korea, Republic of
  6. Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of

    Abstract

    Background/Aims: To analyze the clinical manifestations and results of treatment for patients with retinoblastoma in Korea.

    Methods: We retrospectively analyzed the medical records of 70 children (92 eyes) diagnosed with retinoblastoma and treated between 2000 and 2006. Data on gender, age at diagnosis, laterality, presenting sign, classification of tumor, treatment modality, and prognosis were collected.

    Results: The most common presenting sign was leukocoria (80%). 31.4% developed bilateral retinoblastoma. Using the International Classification of Retinoblastoma, 7.5% were group A, 23.8% were group B, 6.3% were group C, 38.8% were group D, and 23.8% were group E. 26.1% of eyes were treated with chemoreduction and/or focal therapy, namely, they achieved globe preservation and all other eyes were enucleated. The globe preservation was achieved in 100% of group A, 77.8% of group B, 66.7% of group C, and 26.7% of group D.

    Conclusions: In Korea, most of children with retinoblastoma showed advanced stage of tumor at time of diagnosis and although they are treated with update therapeutic approach according to the newly introduced classification, the rate of globe preservation did not reach developed countries. Increased surveillance should be performed.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.