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Ocular and Systemic Factors Related to Intraocular Pressure in Japanese Adults: The Tajimi Study
  1. Kazuhide Kawase (mekawase{at}gifu-u.ac.jp),
  2. Atsuo Tomidokoro,
  3. Makoto Araie,
  4. Aiko Iwase,
  5. Tetsuya Yamamoto
  1. Department of Ophthalmology, Gifu University Graduate School of Medicine, Japan
  2. Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Japan
  3. Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Japan
  4. Department of Ophthalmology, Tajimi Municipal Hospital, Japan
  5. Department of Ophthalmology, Gifu University Graduate School of Medicine, Japan

    Abstract

    Backgrounds: Since intraocular pressure (IOP) and age are consistent risk factors of glaucoma, it is of special interest to know the association between IOP and possibly relating factors including age in Japan where high prevalence of normal-tension glaucoma has been reported. The aim of this report was to evaluate the distribution of and factors related to applanation IOP in a population-based study in Japan.

    Methods: A randomly sampled 3,021 residents (response rate, 78.1%) of Tajimi City, aged 40 years or older underwent screening examinations including measurements of IOP with Goldmann applanation tonometry and central corneal thickness.

    Results: Among right eyes without glaucoma, glaucoma suspect or other disorders which could affect correct IOP measurements, IOP averaged 14.6 ± 2.7 (standard deviation) and 14.5 ± 2.5 mmHg in men and women, respectively, with no significant inter-gender difference (P=0.342). Multiple regression analyses revealed that age was significantly negatively correlated with IOP [nonstandardized beta (B)=-0.020/year, P=0.0001]. Higher body mass index (B=0.14/BMI, P<0.0001), higher mean blood pressure (B=0.022/mmHg, P<0.0001), a history of diabetes (P=0.0019), thicker cornea (B=0.014/ƒÊm, P<0.0001), higher myopia (B=0.055/diopters, P=0.0043) and steeper corneal curvature (B=-0.72/mm, P=0.0002) were also significantly correlated with higher IOP.

    Conclusions: In an adult Japanese population, applanation IOP averaged 14.5 mmHg and was negatively correlated with age after adjusting for other related factors. Positive correlation between IOP and myopia was found.

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