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Prevalence and Risk Factors of Retinal Vein Occlusion in an Asian Population
  1. Lyndell L Lim (limllp{at}unimelb.edu.au),
  2. Ning Cheung (dannycheung{at}hotmail.com),
  3. Jie Jin Wang (jiejin_wang{at}wmi.usyd.edu.au),
  4. FM Amirul Islam (fislam{at}unimelb.edu.au),
  5. Paul R Mitchell (paul_mitchell{at}wmi.usyd.edu.au),
  6. Seang-Mei Saw (cofsawsm{at}nus.edu.sg),
  7. Tin Aung (aung_tin{at}yahoo.co.uk),
  8. Tien Yin Wong (twong{at}unimelb.edu.au)
  1. Centre for Eye Research, Melbourne University, Australia
  2. Centre for Eye Research, Melbourne University, Australia
  3. Centre for Vision Research, U of Sydney, Australia
  4. Centre for Eye Research, Melbourne University, Australia
  5. University of Sydney, Australia
  6. National University of Singapore, Singapore
  7. Institute of Ophthalmology, Singapore
  8. University of Melbourne, Australia

    Abstract

    Aim: To describe the prevalence and risk factors of retinal vein occlusion (RVO) in an Asian population.

    Methods: The Singapore Malay Eye Study is a population-based, cross-sectional study of 3,280 (78.7%) Malay adults (aged 40 to 80 years) living in Singapore. All participants underwent retinal photography, standardised interview, clinical examinations, and laboratory investigations. RVO (central or branch) was graded based on the Blue Mountains Eye Study (BMES) protocol from retinal photographs.

    Results: The overall prevalence of RVO was 0.7% (n=22) (95% confidence intervals [CI]: 0.4, 1.0) (18 branch and 5 central RVO cases). There was no significant gender difference in RVO prevalence. RVO was associated with higher systolic blood pressure (age-adjusted odds ratio (OR) per SD increase 1.54, CI: 1.02, 2.31), ocular perfusion pressure (OR per SD increase 1.49, CI: 1.03, 2.16), a history of angina (OR 5.18, CI: 1.49, 18.0) and heart attack (OR 4.26, CI: 1.47, 12.3), and higher total cholesterol (OR per SD increase 1.55, CI: 1.07, 2.24) and LDL (OR per SD increase 1.47, CI: 1.02, 2.12) cholesterol levels.

    Conclusions: The prevalence of RVO in this Asian population was lower than Caucasian whites in the BMES, although the systemic associations of RVO were largely similar to BMES and other studies.

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